Genetic and environmental effects on mortality before age 70 years
Genetic and environmental effects on mortality before age 70 years
复制标题
DOI：
10.1097/ede.0b013e3181692769
复制
发表时间：
2008-05-01
期刊：
影响因子：
5.4
通讯作者：
Sorensen, Thorkild I. A.
中科院分区：
文献类型：
--
作者：
Petersen, Liselotte;Andersen, Per Kragh;Sorensen, Thorkild I. A.
背景：根据对双胞胎的研究，许多疾病的风险和死亡率都受到家族因素的影响，这是遗传和环境因素共同作用的结果。基于不同假设的收养研究也可以用来分别估计遗传和环境对死亡率的影响。方法：通过估计丹麦被领养人及其生物全同胞和同父异母兄弟姐妹的总死亡率和原因特定死亡率，研究遗传对70岁前死亡率的影响。调查被领养人及其领养兄弟姐妹在生活中同时分享的家庭环境影响。这项研究的基础是丹麦在1924年至1947年期间正式批准的14,425个非家庭收养，记录在丹麦收养登记册上。从这份登记册中，我们选择了1552名“病例”被领养人(他们在1993年4月1日之前死亡)和1710名在那一天还活着的“非病例”被领养人。结果：与非病例被收养人的生物兄弟姐妹的死亡率相比，因感染和血管原因死亡的生物兄弟姐妹的死亡率约高2倍，自然原因和各种原因的死亡率增加了约45%。结论：感染、血管原因、自然原因和所有原因对死亡兄弟姐妹的死亡率有遗传效应，但没有迹象表明共有的兄弟姐妹环境的影响。
Background: There is a familial influence on risk of many diseases and on mortality in general, which, according to studies of twins, is due to a combination of genetic and environmental effects. Adoption studies, which rest on different assumptions, may also be used to estimate separately the genetic and environmental effects on rate of dying.Methods: The genetic influence on the rate of dying before age 70 years was investigated by estimation of the associations in total and cause-specific mortality of Danish adoptees and their biologic full and half siblings. Familial environmental influences shared at the same time in life were investigated in adoptees and their adoptive siblings. The study basis is the 14,425 nonfamilial adoptions formally granted in Denmark during the period 1924 through 1947, recorded in the Danish Adoption Register. From this register we selected the 1552 "case" adoptees (who died before 01 April 1993) and 1710 "noncase" adoptees alive at that date. The siblings of the case and noncase adoptees were traced in the archives and followed for-ward, and the rates of dying before age 70 years were compared.Results: Compared with mortality of the biologic siblings of noncase adoptees, the mortality of biologic siblings of dead adoptees was approximately 2-fold higher for death with infections and vascular causes, and around 45% increased for natural causes and for all causes.Conclusion: The results suggest that there is a genetic effect on the rate of death with infections, vascular causes, natural causes and all causes, whereas there is no indication of an influence of shared sibling environment.