The effect of furosemide and bumetanide on cerebrospinal fluid formation.
The effect of furosemide and bumetanide on cerebrospinal fluid formation.
复制标题
呋塞米和布美他尼对脑脊液形成的影响。
DOI：
10.1016/0006-8993(81)91071-4
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发表时间：
1981
期刊：
影响因子：
2.9
通讯作者：
LanghamJr,MR
中科院分区：
文献类型：
--
作者：
Vogh,BP;LanghamJr,MR
完全抑制碳酸酐酶可最大限度地减少脑脊液流量 40-60%34。我们已经证实，乙酰唑胺 30 mg/kg 静脉注射可以最大程度地减少兔子的脑脊液流量，但发现静脉注射 50 mg/kg 呋塞米后，与对照相比仅减少约 20%。基于呋塞米对碳酸酐酶的亲和力，呋塞米的这种作用与对脉络丛（可能还有脑脊液分泌的其他位点）碳酸酐酶的特异性但部分抑制一致。布美他尼对碳酸酐酶的亲和力比呋塞米低 7 倍，对肾电解质转运过程的抑制作用比呋塞米高 14-40 倍2,18,30，但不会减少脑脊液流量。
Complete inhibition of carbonic anhydrase maximally reduces CSF flow 40–60%34. We have confirmed that CSF flow in rabbits may be maximally decreased in this way by acetazolamide 30 mg/kg i.v., but have found only about 20% reduction from control after furosemide at 50 mg/kg i.v. This effect of furosemide is consistent with specific but partial inhibition of carbonic anhydrase of choroid plexus (and perhaps other sites of CSF secretion) based on the affinity of furosemide for carbonic anhydrase. Bumetanide, with 7 times lower affinity for carbonic anhydrase and 14–40 times higher inhibition of renal electrolyte transport processes than furosemide2,18,30, did not decrease CSF flow.