Regiocontrol in the palladium(II)-catalysed oxycarbonylation of unsaturated polyols
Regiocontrol in the palladium(II)-catalysed oxycarbonylation of unsaturated polyols
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DOI：
10.3998/ark.5550190.0006.505
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发表时间：
2005-01-01
期刊：
影响因子：
0.9
通讯作者：
Gracza, T
中科院分区：
文献类型：
--
作者：
Babjak, M;Zálupsky, P;Gracza, T
The regiocontrol of palladium(II)-catalysed oxycarbonylation of pentenetriols was studied for its potential exploitation in the carbonylation methodology for construction of tetrahydrofuran derivatives with defined stereochemistry. Synthesis of model substrates, the partially protected pentenetriols with diverse protecting groups was carried out starting from D-mannitol. The availability of the protecting group for carbonylation was tested, from the chemo-, regio-, and stereoselectivity point of view. It was found that course as well as stereochemistry of the process may be controlled by beta-OH with silyl protected O-function in the alpha-position.
