Upper Alpha Based Neurofeedback Training in Chronic Stroke: Brain Plasticity Processes and Cognitive Effects.
Upper Alpha Based Neurofeedback Training in Chronic Stroke: Brain Plasticity Processes and Cognitive Effects.
复制标题
DOI：
10.1007/s10484-017-9353-5
复制
发表时间：
2017-03
影响因子：
3
通讯作者：
Wood G
中科院分区：
文献类型：
--
作者：
Kober SE;Schweiger D;Reichert JL;Neuper C;Wood G
在本研究中，我们研究了基于上阿尔法的神经反馈（NF）训练对中风幸存者的脑电活动和认知功能的影响。因此，两名患有记忆缺陷的单一慢性脑卒中患者（受试者A患有双侧蛛网膜下腔出血；受试者B患有左脑中动脉缺血性脑卒中）和一个健康老年人对照组（N = 24）接受了多达10次的NF训练。为了评估 NF 训练效果，所有参与者都进行了多通道脑电图 (EEG) 静息测量和神经心理学测试组，以评估 NF 训练前后的不同认知功能。与预评估相比，中风患者在成功进行 NF 训练后，记忆功能有所改善。在 NF 训练之前，受试者 B 在未受影响的半球上具有病理性 delta (0.5–4 Hz) 和上限 alpha (10–12 Hz) 功率最大值。经过 NF 训练后，他表现出这些脑电图频率的更加双边和“标准化”的地形分布。在 NF 训练开始之前，健康参与者以及受试者 A 的脑电图地形图均未表现出任何异常。因此，在比较评估前和评估后时，没有观察到这些参与者的脑电图活动的地形分布发生变化。因此，我们的结果表明，基于上α的神经功能训练一方面对记忆功能有积极影响，另一方面导致具有病理性大脑激活模式的中风患者的皮质“正常化”，这强调了神经功能作为神经康复工具的潜在有用性。
In the present study, we investigated the effects of upper alpha based neurofeedback (NF) training on electrical brain activity and cognitive functions in stroke survivors. Therefore, two single chronic stroke patients with memory deficits (subject A with a bilateral subarachnoid hemorrhage; subject B with an ischemic stroke in the left arteria cerebri media) and a healthy elderly control group (N = 24) received up to ten NF training sessions. To evaluate NF training effects, all participants performed multichannel electroencephalogram (EEG) resting measurements and a neuropsychological test battery assessing different cognitive functions before and after NF training. Stroke patients showed improvements in memory functions after successful NF training compared to the pre-assessment. Subject B had a pathological delta (0.5–4 Hz) and upper alpha (10–12 Hz) power maximum over the unaffected hemisphere before NF training. After NF training, he showed a more bilateral and “normalized” topographical distribution of these EEG frequencies. Healthy participants as well as subject A did not show any abnormalities in EEG topography before the start of NF training. Consequently, no changes in the topographical distribution of EEG activity were observed in these participants when comparing the pre- and post-assessment. Hence, our results show that upper alpha based NF training had on the one hand positive effects on memory functions, and on the other hand led to cortical “normalization” in a stroke patient with pathological brain activation patterns, which underlines the potential usefulness of NF as neurological rehabilitation tool.