POSITRON-EMISSION TOMOGRAPHY AND PERSONALITY-DISORDERS
POSITRON-EMISSION TOMOGRAPHY AND PERSONALITY-DISORDERS
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DOI：
10.1038/npp.1994.3
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发表时间：
1994-02-01
影响因子：
7.6
通讯作者：
SCHULZ, SC
中科院分区：
文献类型：
--
作者：
GOYER, PF;COHEN, RM;SCHULZ, SC
本研究使用正电子发射断层扫描检查脑葡萄糖代谢率（CMRG）在17例患者与DSM III-R诊断的人格障碍。在17例人格障碍患者中，攻击性冲动困难的生活史与小脑耳道线（CML）上方约40 mm处的横断平面额叶皮质中的区域CMRG之间存在显著的负相关（r =-0.56，p = 0.17）。诊断组包括反社会（n = 6），边缘（n = 6），依赖（n = 2）和自恋（n = 3）。区域CMRG在6个反社会的患者和6个边缘患者进行了比较，对照组的43名受试者使用协方差分析与年龄和性别作为协变量。在边缘型人格障碍组中，在CML上方约81 mm的轴向平面中，额叶皮质代谢显著降低，而在CML上方约53 mm的轴向平面中，额叶皮质代谢显著增加（分别为F[1，45] = 8.65，p = 0.005; F[1，45] = 7.68，p = 0.008）。
This study used positron-emission tomography to examine cerebral metabolic rates of glucose (CMRG) in 17 patients with DSM III-R diagnoses of personality disorder. Within the group of 17 personality disorder patients, there was a significant inverse correlation between a life history of aggressive impulse difficulties and regional CMRG in the frontal cortex of the transaxial plane approximately 40 mm above the canthomeatal line (CML) (r = - .56, p = 0.17). Diagnostic groups included antisocial (n = 6), borderline (n = 6), dependent (n = 2), and narcissistic (n = 3). Regional CMRG in the six antisocial patients and in the six borderline patients was compared to a control group of 43 subjects using an analysis of covariance with age and sex as covariates. In the borderline personality disorder group, there was a significant decrease in frontal cortex metabolism in the transaxial plane approximately 81 mm above the CML and a significant increase in the transaxial plane approximately 53 mm above the CML (F[1,45] = 8.65, p = .005; and F[1,45] = 7.68, p = .008, respectively).