Pentoxifylline and electromagnetic field improved bone fracture healing in rats.
Pentoxifylline and electromagnetic field improved bone fracture healing in rats.
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DOI：
10.2147/dddt.s89669
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发表时间：
2015
期刊：
影响因子：
--
通讯作者：
Guner R
中科院分区：
文献类型：
--
作者：
Atalay Y;Gunes N;Guner MD;Akpolat V;Celik MS;Guner R
本研究的目的是评估磷酸二酯酶抑制剂戊茶碱（PTX），电磁场（EMF），以及两种材料的混合物对大鼠骨折愈合模型的影响。将80只雄性Wistar大鼠随机分为4组：A组，股骨骨折模型不作任何处理，B组，股骨骨折模型给予PTX 50 mg/kg/d腹腔注射，C组，股骨骨折模型给予电磁场1.5±0.2 Mt/50 Hz/6 h/d治疗，D组，股骨骨折模型给予PTX 50 mg/kg/d腹腔注射。D组，股骨骨折模型，腹腔注射PTX 50 mg/kg/d，电磁场1.5±0.2 Mt/50 Hz/6 h/d。B组和C组的骨折愈合情况明显优于A组（P<0.05），而D组的骨折愈合情况与A组无明显差异（P>0.05）。可以得出结论，特定EMF和PTX对骨折愈合具有积极作用，但当组合使用时，可能不是有益的。
The aim of this study was to evaluate the effects of a phosphodiesterase inhibitor pentoxifylline (PTX), electromagnetic fields (EMFs), and a mixture of both materials on bone fracture healing in a rat model. Eighty male Wistar rats were randomly divided into four groups: Group A, femur fracture model with no treatment; Group B, femur fracture model treated with PTX 50 mg/kg/day intraperitoneal injection; Group C, femur fracture model treated with EMF 1.5±0.2 Mt/50 Hz/6 hours/day; and Group D, femur fracture model treated with PTX 50 mg/kg/day intraperitoneal injection and EMF 1.5±0.2 Mt/50 Hz/6 hours/day. Bone fracture healing was significantly better in Group B and Group C compared to Group A (P<0.05), but Group D did not show better bone fracture healing than Group A (P>0.05). It can be concluded that both a specific EMF and PTX had a positive effect on bone fracture healing but when used in combination, may not be beneficial.