Manipulating circadian clock neuron firing rate resets molecular circadian rhythms and behavior.
Manipulating circadian clock neuron firing rate resets molecular circadian rhythms and behavior.
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DOI：
10.1038/nn.3937
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发表时间：
2015-03
影响因子：
25
通讯作者：
McMahon DG
中科院分区：
文献类型：
--
作者：
Jones JR;Tackenberg MC;McMahon DG
为了研究分子、电和行为昼夜节律之间的相互作用，我们将视交叉上核(SCN)放电率的光遗传操作与生物发光成像和运动活动监测相结合。操控放电频率重置体内和体外的昼夜节律，而这种重置需要尖峰和网络通信。这表明，SCN的放电频率是昼夜节律起搏的基础，既是分子时钟的输入，也是分子时钟的输出。
To examine the interaction between molecular, electrical, and behavioral circadian rhythms, we combined optogenetic manipulation of suprachiasmatic nucleus (SCN) firing rate with bioluminescence imaging and locomotor activity monitoring. Manipulating firing rate reset circadian rhythms both ex vivo and in vivo and this resetting required spikes and network communication. This suggests that SCN firing rate is fundamental to circadian pacemaking as both an input onto and output of the molecular clockworks.