EFFECT OF ACUTE CHANGES IN HEART-RATE ON DOPPLER PULMONARY-ARTERY ACCELERATION TIME IN A PORCINE MODEL
EFFECT OF ACUTE CHANGES IN HEART-RATE ON DOPPLER PULMONARY-ARTERY ACCELERATION TIME IN A PORCINE MODEL
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DOI：
10.1378/chest.94.5.994
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发表时间：
1988-11-01
期刊：
影响因子：
9.6
通讯作者：
HENRY, WL
中科院分区：
文献类型：
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作者：
GARDIN, JM;SATO, DA;HENRY, WL
肺动脉 (PA) 加速时间 (AT) 的多普勒测量已在临床上用于估计 PA 压力。然而，这些研究主要是在没有心动过速的患者中进行的。为了确定心率急性变化对 PA AT 的影响，对七只闭胸猪进行了心房起搏研究。脉冲多普勒 PA 流速记录是从胸骨旁位置以 100 至 140 次/分钟的起搏速率获得的。 PA 压力在整个起搏速率范围内保持恒定（平均 .+-. SD = 14 .+-. 5 mm Hg）。当 PA 多普勒测量结果在心率为 100 和 140 次/分钟时进行比较时，心率较高时，加速时间（110 .+-. 12 与 83 .+-. 11 毫秒，p < 0.01）和射血时间 (ET)（315 .+-. 23 与 237 .+-. 21 毫秒，p < 0.01）均有所下降。相比之下，PA 峰值流速（69 .+-. 15 与 62 .+-. 18 cm/s）或 AT/ET 比率（0.35 .+-. 02 与 36 .+-. .03）没有变化。因此，在估计心动过速阶段的 PA 压力时，PA AT/ET 比率可能是比 PA 加速时间更有用的测量值。
Doppler measurements of pulmonary artery (PA) acceleration time (AT) have been used clinically to estimate PA pressure. However, these studies have been performed primarily in patients without tachycardia. To determine the effect of acute changes in heart rate on PA AT, atrial pacing studies were performed in seven closed-chest pigs. Pulsed Doppler PA flow velocity recordings were obtained from a parasternal position at pacing rates from 100 to 140 beats/min. PA pressure remained constant (mean .+-. SD = 14 .+-. 5 mm Hg)over the entire range of paced rates. When PA Doppler measurements were compared at heart rates of 100 and 140 beats/min, there were decreases at the higher heart rate in both acceleration time (110 .+-. 12 vs 83 .+-. 11 ms, p < 0.01) and ejection time (ET) (315 .+-. 23 vs 237 .+-. 21 ms, p < 0.01). In contrast, there was no change in either PA peak flow velocity (69 .+-. 15 vs 62 .+-. 18 cm/s) or the ratio of AT/ET (0.35 .+-. 02 vs 36 .+-. .03). Consequently, when estimating PA pressure in stages of tachycardia, the PA AT/ET ratio may be a more useful measurement than PA acceleration time.