Coming of Age for Autotaxin and Lysophosphatidate Signaling: Clinical Applications for Preventing, Detecting and Targeting Tumor-Promoting Inflammation.
Coming of Age for Autotaxin and Lysophosphatidate Signaling: Clinical Applications for Preventing, Detecting and Targeting Tumor-Promoting Inflammation.
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DOI：
10.3390/cancers10030073
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发表时间：
2018-03-15
期刊：
影响因子：
5.2
通讯作者：
Brindley DN
中科院分区：
文献类型：
--
作者：
Benesch MGK;MacIntyre ITK;McMullen TPW;Brindley DN
在细胞培养物中发现自分泌运动因子四分之一个世纪后，自分泌运动因子-溶血磷脂酸 (LPA)-磷酸脂磷酸酶轴现已成为治疗慢性炎症、减轻纤维化进展和提高现有癌症化疗和放疗疗效的有前景的临床靶点。近一半关于该轴的文献是在过去五年内出版的。在癌症生物学中，LPA 信号传导越来越被认为是建立肿瘤微环境过程中慢性炎症进展的核心介质，从而促进癌症生长、免疫逃避、转移和治疗抵抗。在这篇综述中，我们将总结在了解 LPA 信号与慢性炎症和癌症相关的最新进展。我们还将提供有关 LPA 信号抑制剂在预防癌症发生方面的应用的观点，作为辅助剂，通过阻止癌症或癌症治疗本身引起的炎症以及破坏肿瘤微环境来扩展当前癌症治疗的功效。总体而言，LPA 是一种介导多种生物效应的简单分子，可通过自分泌运动因子、LPA 受体或通过脂质磷酸磷酸酶降解 LPA 来靶向其产生水平。用于这些应用的药物很快就会进入临床实践。
A quarter-century after the discovery of autotaxin in cell culture, the autotaxin-lysophosphatidate (LPA)-lipid phosphate phosphatase axis is now a promising clinical target for treating chronic inflammatory conditions, mitigating fibrosis progression, and improving the efficacy of existing cancer chemotherapies and radiotherapy. Nearly half of the literature on this axis has been published during the last five years. In cancer biology, LPA signaling is increasingly being recognized as a central mediator of the progression of chronic inflammation in the establishment of a tumor microenvironment which promotes cancer growth, immune evasion, metastasis, and treatment resistance. In this review, we will summarize recent advances made in understanding LPA signaling with respect to chronic inflammation and cancer. We will also provide perspectives on the applications of inhibitors of LPA signaling in preventing cancer initiation, as adjuncts extending the efficacy of current cancer treatments by blocking inflammation caused by either the cancer or the cancer therapy itself, and by disruption of the tumor microenvironment. Overall, LPA, a simple molecule that mediates a plethora of biological effects, can be targeted at its levels of production by autotaxin, LPA receptors or through LPA degradation by lipid phosphate phosphatases. Drugs for these applications will soon be entering clinical practice.
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自分泌运动因子-溶血磷脂酸轴在癌症对化疗和放疗的抵抗中的作用。
DOI：
10.1016/j.bbalip.2012.08.015
发表时间：
2013-01
期刊：
Biochimica et biophysica acta
影响因子：
--
作者：
Brindley DN;Lin FT;Tigyi GJ
通讯作者：
Tigyi GJ
影响因子：
4.6
作者：
Bekele RT;Venkatraman G;Liu RZ;Tang X;Mi S;Benesch MG;Mackey JR;Godbout R;Curtis JM;McMullen TP;Brindley DN
通讯作者：
Brindley DN
影响因子：
4.8
作者：
Benesch, Matthew G. K.;Tang, Xiaoyun;Brindley, David N.
通讯作者：
Brindley, David N.
影响因子：
37.8
作者：
Bouchareb, Rihab;Mahmut, Ablajan;Mathieu, Patrick
通讯作者：
Mathieu, Patrick
影响因子：
--
作者：
Cerutis DR;Weston MD;Ogunleye AO;McVaney TP;Miyamoto T
通讯作者：
Miyamoto T