Contrasting patterns of sequence divergence and base composition between Drosophila introns and intergenic regions
Contrasting patterns of sequence divergence and base composition between Drosophila introns and intergenic regions
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DOI：
10.1098/rsbl.2006.0521
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发表时间：
2006-12-22
期刊：
影响因子：
3.3
通讯作者：
Stephan, Wolfgang
中科院分区：
文献类型：
--
作者：
Ometto, Lino;De Lorenzo, David;Stephan, Wolfgang
果蝇的两个非编码 DNA 类别（内含子和基因间区域）表现出截然不同的进化模式。基因间区域的 GC 含量显着较高，并影响其核苷酸变异程度。分歧与基因间区域的重组率正相关，但在内含子中则不然。我们认为这些差异是由于不同的选择性约束而不是突变或重组机制造成的。
Two non-coding DNA classes, introns and intergenic regions, of Drosophila melanogaster exhibit contrasting evolutionary patterns. GC content is significantly higher in intergenic regions and affects their degree of nucleotide variability. Divergence is positively correlated with recombination rate in intergenic regions, but not in introns. We argue that these differences are due to different selective constraints rather than mutational or recombinational mechanisms.