Striatal lesions in the mouse disrupt acquisition and retention, but not implicit learning, in the SILT procedural motor learning task
Striatal lesions in the mouse disrupt acquisition and retention, but not implicit learning, in the SILT procedural motor learning task
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DOI：
10.1016/j.brainres.2007.09.017
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发表时间：
2007-12-14
期刊：
影响因子：
2.9
通讯作者：
Dunnett, Stephen B.
中科院分区：
文献类型：
--
作者：
Brooks, Simon P.;Trueman, Rebecca C.;Dunnett, Stephen B.
患有亨廷顿病（HD）的人被发现有内隐学习缺陷，由此他们通常不能检测嵌入在随机呈现的刺激中的重复序列。采用9孔箱装置设计了操作性系列内隐学习任务（SILT），以探讨HD动物模型的内隐学习缺陷。本研究使用小鼠来确定“早期”纹状体病变是否会阻止SILT的获得，并证实先前的研究结果，即训练后“晚期病变”会损害任务表现的保持。SILT是一个两阶段的任务，其中一个初始的刺激光（Si）呈现在五个可能的位置之一。对S1的正确的鼻子戳反应导致该光被熄灭，并且第二个明显随机的光呈现（S2）。一个正确的鼻子戳到S2导致奖励。在明显随机的刺激光呈现中，嵌入了可预测的S1/S2组合。两个病变组（“早期”采集前病变和“晚期”采集后病变）均表现出对S1的反应时间增加，与假手术对照组相比，晚期病变组还记录到任务准确性降低。早期损伤组在任务获得过程中对S2刺激的反应延迟也增加，晚期损伤组的任务保持也是如此。在采集期间，对照组和早期病变组之间的S2响应准确性无差异。在晚期病变组的病变后，两个病变组表现出对S2刺激的准确性降低，因为对照组在整个测试期间提高了其性能，而两个病变组的准确性在较低的性能水平上保持稳定。所有三个实验组都能够利用嵌入的可预测信息。现有的数据表明，纹状体是重要的获得和保持的运动学习任务，但不发挥作用，在学习的内隐信息。(C)2007 Elsevier B. V.保留所有权利。
People with Huntington's disease (HD) have been found to have an implicit learning deficit whereby they are typically unable to detect repeated sequences embedded within randomly presented stimuli. The operant serial implicit learning task (SILT) was designed to probe animal models of HD for implicit learning deficits using the 9-hole box apparatus. The present study used mice to determine whether "early" striatal lesions would prevent SILT acquisition and to confirm previous findings that post-training "late lesions" would impair the retention of task performance. The SILT is a two-phase task whereby an initial stimulus light (Si) presentation was presented in one of five possible locations. A correct nose-poke response to the S1 resulted in this light being extinguished and a second, apparently random light presentation (S2). A correct nose-poke to S2 resulted in a reward. Within the apparently random stimulus light presentations, a predictable S1/S2 combination was embedded. Both lesion groups ("early" pre-acquisition and "late" post-acquisition lesions) demonstrated increased reaction times to S1, with the late-lesion group also recording reduced task accuracy when compared with the sham control group. The early-lesion group also demonstrated increased response latencies for the S2 stimuli during task acquisition, this was also true for task retention in the late-lesion group. No difference between the control group and early-lesion group was found for the S2 response accuracy during the acquisition period. After the lesioning of the late-lesion group, both lesion groups demonstrated reduced accuracy to the S2 stimuli as the control group improved their performance throughout the test period, while the accuracy of both lesion groups remained stable at a lower performance level. All three experimental groups were able to utilize the embedded predictable information. The present data suggest that the striatum is important for the acquisition and retention of motor learning tasks, but does not play a role in the learning of implicit information. (C) 2007 Elsevier B.V. All rights reserved.