Serum alkaline phosphatase levels associate with elevated serum C-reactive protein in chronic kidney disease.
Serum alkaline phosphatase levels associate with elevated serum C-reactive protein in chronic kidney disease.
复制标题
血清碱性磷酸酶水平与慢性肾脏疾病中血清C反应蛋白升高相关。
DOI：
10.1038/ki.2010.356
复制
发表时间：
2011-01
影响因子：
19.6
通讯作者：
Beddhu S
中科院分区：
文献类型：
--
作者：
Damera S;Raphael KL;Baird BC;Cheung AK;Greene T;Beddhu S
在一般人群中，血清碱性磷酸酶浓度高与血清C反应蛋白（CRP）水平升高相关。为了检验这种关联是否独立于血清维生素D水平或在慢性肾脏病（CKD）中改变，我们使用来自14，420名成人参与者的国家健康和营养检查调查III的数据确定这种关联是否存在，其中5.7%患有CKD（定义为估计的肾小球滤过率< 60 ml/min/1.73 m2）。对于血清碱性磷酸酶每增加一倍，血清CRP升高（超过3 mg/l）的几率在非慢性和CKD亚群中分别增加2.73倍和2.50倍。各亚群间血清碱性磷酸酶每加倍与CRP升高的回归系数无显著差异。对血清25-羟基（OH）维生素D水平的额外调整没有实质性改变结果。因此，在慢性和非CKD人群中，血清碱性磷酸酶与CRP升高的相关性与血清25-OH维生素D无关。因此，血清碱性磷酸酶可能是炎症环境的标志物。
High serum alkaline phosphatase concentrations are associated with elevated serum C-reactive protein (CRP) levels in the general population. To examine whether this association is independent of serum vitamin D levels or modified in chronic kidney disease (CKD), we determined if such associations exist using data from the National Health and Nutrition Examination Survey III of 14,420 adult participants in which 5.7% had CKD (defined as estimated glomerular filtration rate < 60 ml/min per 1.73m2). For each doubling of serum alkaline phosphatase, the odds of elevated serum CRP (over 3mg/l) were increased 2.73-fold in the non-chronic and 2.50-fold in the CKD sub-populations, respectively. Regression coefficients of each doubling of serum alkaline phosphatase with elevated CRP were not significantly different in between the sub-populations. Additional adjustment for the serum 25-hydroxy (OH) vitamin D level did not substantively change the results. Thus, associations of serum alkaline phosphatase with elevated CRP are independent of serum 25-OH vitamin D in the chronic and non-CKD populations. Hence, serum alkaline phosphatase might be a marker of the inflammatory milieu.