Effects of Qingshen Granules on the Oxidative Stress-NF/kB Signal Pathway in Unilateral Ureteral Obstruction Rats.
Effects of Qingshen Granules on the Oxidative Stress-NF/kB Signal Pathway in Unilateral Ureteral Obstruction Rats.
复制标题
清肾颗粒对单侧输尿管梗阻大鼠氧化应激-NF/kB信号通路的影响
DOI：
10.1155/2018/4761925
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发表时间：
2018
期刊：
影响因子：
--
通讯作者：
Zhang L
中科院分区：
文献类型：
--
作者：
Jin H;Wang Y;Wang D;Zhang L
背景。NF- κ B （NF/kB）信号通路的激活在肾小管上皮-间质转化（epithelial-mesenchymal transition， EMT）和肾间质纤维化（renal inter质fibrosis， RIF）过程中起重要作用。肾脏氧化应激反应的过程是通过过量活性氧（ROS）的产生激活NF/kB信号通路。清肾颗粒是一种治疗慢性肾衰竭的有效中药方剂。既往研究证实，QSG对单侧输尿管梗阻（UUO）大鼠的RIF有抑制作用。本研究以UUO大鼠为实验对象，研究芪多糖对氧化应激和NF/kB信号激活的影响。将70只雄性SD大鼠随机分为假手术组、UUO模型组、清肾颗粒高、中、低剂量组、PDTC组和坎地沙坦组，每组10只。我们的研究表明氧化应激- nf /kB信号通路参与了UUO肾间质纤维化的形成。QSG可能通过抑制氧化应激- nf /kB信号通路、减轻炎症和改善肾小管EMT来预防RIF。
Background. The activation of NF-kappa B (NF/kB) signaling pathway plays an important role in the process of epithelial-mesenchymal transition (EMT) and renal interstitial fibrosis (RIF) in renal tubules. The process of oxidative stress reaction in kidney is via excessive reactive oxygen species (ROS) production to activate NF/kB signaling pathway. Qingshen Granule (QSG) is an effective Chinese formula utilized to treat chronic renal failure. Previous studies confirmed that QSG could inhibit RIF in unilateral ureteral obstruction (UUO) rats. In this study, we used UUO rats to investigate the effects of QSG on oxidative stress and the activation of NF/kB signaling. Seventy male Sprague-Dawley (SD) rats were randomly divided into a sham group, UUO model group, Qingshen Granules (QSG) high-dose, medium-dose, and low-dose groups, PDTC group, and candesartan group (10 rats in each group). Our study demonstrated that oxidative stress-NF/kB signal pathway contributed to the formation of UUO renal interstitial fibrosis. QSG may protect against RIF by inhibiting the oxidative stress-NF/kB signal pathway, reducing inflammation, and improving renal tubular EMT.
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影响因子：
6.1
作者：
Dudas, Paul L.;Argentieri, Rochelle L.;Farrell, Francis X.
通讯作者：
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DOI：
10.1124/jpet.105.088062
发表时间：
2005-10-01
影响因子：
3.5
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DOI：
10.1007/s11596-016-1663-y
发表时间：
2016-12-01
影响因子：
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作者：
Jia, Yu;Wang, Lu;Chen, Gang
通讯作者：
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影响因子：
2.5
作者：
Higashi, Keishi;Oda, Takashi;Kumagai, Hiroo
通讯作者：
Kumagai, Hiroo