Structure/function relationships of CREB/ATF proteins.
Structure/function relationships of CREB/ATF proteins.
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DOI：
10.1111/1523-1747.ep12462126
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发表时间：
1992-06
期刊：
影响因子：
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通讯作者：
J. Hoeffler
中科院分区：
文献类型：
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作者：
J. Hoeffler
信号转导途径最终会聚在转录激活水平，以响应环境刺激产生特定的基因表达模式。由这些信号传导途径介导的转录起始受与基因的控制区结合的特定转录因子的协调表达和/或激活的调节。对转录激活机制的具体见解最近出现在对这些转录因子的结构和功能的研究中。转录反式激活蛋白的CREB/ATF家族最近才被发现，并且似乎提供了响应于细胞信号传导途径的激活剂的基因表达调节与病毒反式激活蛋白的基因表达调节之间的联系。此外，这些蛋白质可能参与生长和分化的正常调节。了解这些蛋白质在生长和分化的正常调节中的作用的性质和重要性，将对理解肿瘤发生期间这些过程的异常调节产生深远的影响。
Signal-transduction pathways converge ultimately at the level of transcriptional activation to produce specific patterns of gene expression in response to environmental stimuli. The initiation of transcription mediated by these signaling pathways is regulated by the coordinate expression and/or activation of specific transcription factors that bind to the control regions of genes. Specific insights into the mechanisms underlying transcriptional activation have recently arisen from studies of the structure and functions of these transcription factors. The CREB/ATF family of transcriptional transactivating proteins has only recently been discovered and appears to provide a link between the regulation of gene expression in response to activators of cellular signaling pathways and the regulation of gene expression by viral transactivating proteins. In addition, these proteins may be involved in the normal regulation of growth and differentiation. Understanding the nature and importance of the role(s) of these proteins in the normal regulation of growth and differentiation will have profound influences on the understanding of the aberrant regulation of these processes during oncogenesis.