Effects of renal venous pressure elevation on renal hemodynamics, urine formation and renin release.
Effects of renal venous pressure elevation on renal hemodynamics, urine formation and renin release.
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肾静脉压升高对肾血流动力学、尿液形成和肾素释放的影响。
DOI：
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发表时间：
1972
期刊：
影响因子：
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通讯作者：
J. Ueda
中科院分区：
文献类型：
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作者：
T. Kishimoto;M. Maekawa;M. Miyazaki;K. Yamamoto;J. Ueda
在戊巴比妥钠麻醉犬，观察了肾静脉压(RVP)升高对肾血流动力学、尿液形成和肾素分泌率(RSR)的影响。RVP逐渐升高至30 mm Hg时，RBF和GFR无明显变化，但RVP高于35 mm Hg时，RBF和GFR显著降低。RVP升高的尿流量反应分为两组：尿流量增加伴钠排泄增加和尿流量减少伴钠排出减少。前者RVP逐渐升高使UNaV、Na/K比值和TCH20显著升高，UKV和COSm无明显变化；后者UNaV、UKV和TCH20降低。肾素分泌率(RSR)是RPF与肾静脉-动脉血浆肾素活性差值的乘积，随RVP升高而显著增加。这种RSR增加似乎与RBF、GFR、尿流量或UNaV的变化无关，并对RSR增加的机制进行了讨论。结论：在RVP升高的情况下，肾小管对钠的处理不是必需的，但肾内压力感受器机制似乎是肾素释放的原因。
Effects of renal venous pressure (RVP) elevation on the renal hemodynamics, urine formation and renin secretion rate (RSR) were studied in the pentobar-bital anesthetized dogs. Gradual increment of RVP produced no changes in RBF and GFR till 30 mmHg but a significant decrease in them at RVP above 35 mmHg. The urine flow response to RVP elevation was divided into two groups: an increased urine flow with an increase of sodium excretion and a decreased urine flow with a decrease of sodium excretion. In the former group, gradual RVP elevation produced a significant increase in UNaV, Na/K ratio and TCH20 without changes in UKV and Cosm, while the latter group showed a decrease in UNaV, UKV and TCH20. Renin secretion rate (RSR), the product of RPF and renal venous-arterial difference of plasma renin activity, increased significantly as function of RVP elevation. This RSR increment seemed to be independent of changes in RBF, GFR, urine flow, or UNaV and the increased mechanism of RSR was discussed. It is concluded that tubular handling of sodium is not essential but intrarenal baroreceptor mechanism seems to be responsible for renin release in case of RVP elevation.