Prognostic value of the Residual Cancer Burden index according to breast cancer subtype: Validation on a cohort of BC patients treated by neoadjuvant chemotherapy
Prognostic value of the Residual Cancer Burden index according to breast cancer subtype: Validation on a cohort of BC patients treated by neoadjuvant chemotherapy
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DOI：
10.1371/journal.pone.0234191
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发表时间：
2020-06-24
期刊：
影响因子：
3.7
通讯作者：
Reyal, Fabien
中科院分区：
文献类型：
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作者：
Hamy, Anne-Sophie;Darrigues, Lauren;Reyal, Fabien
介绍残留癌症负担（RCB）量化新辅助化疗（NAC）后的残留疾病。其预测价值尚未在长期随访的大型队列中得到验证。这项工作的目的是独立评估RCB指数的预后价值取决于BC亚型（管腔，HER 2阳性和三阴性（TNBC））。方法我们回顾性评估了2002年至2012年期间接受NAC治疗的T1-T3 NxM 0 BC患者队列的手术标本的RCB指数。在全球人群中，我们分析了RCB指数与无复发生存期（RFS）和总生存期（OS）之间的关系，并按BC亚型分层。结果共纳入717例患者（管腔型BC（n = 222，31%），TNBC（n = 319，44.5%），HER 2阳性（n = 176，24.5%））。中位随访99.9个月后，RCB指数与RFS显著相关。与RCB-I组相比，RCB-0组患者的预后相似，而RCB-II和RCB-III组患者的复发风险增加（RCB-II vs RCB-0：HR = 3.25 CI [2.1-5.1] vs RCB-0：HR = 5.6 CI [3.5-8.9]p
Introduction The Residual Cancer Burden (RCB) quantifies residual disease after neoadjuvant chemotherapy (NAC). Its predictive value has not been validated on large cohorts with long-term follow up. The objective of this work is to independently evaluate the prognostic value of the RCB index depending on BC subtypes (Luminal,HER2-positive and triple negative (TNBCs)). Methods We retrospectively evaluated the RCB index on surgical specimens from a cohort of T1-T3NxM0 BC patients treated with NAC between 2002 and 2012. We analyzed the association between RCB index and relapse-free survival (RFS), overall survival (OS) among the global population, after stratification by BC subtypes. Results 717 patients were included (luminal BC (n = 222, 31%), TNBC (n = 319, 44.5%),HER2-positive (n = 176, 24.5%)). After a median follow-up of 99.9 months, RCB index was significantly associated with RFS. The RCB-0 patients displayed similar prognosis when compared to the RCB-I group, while patients from the RCB-II and RCB-III classes were at increased risk of relapse (RCB-IIversusRCB-0: HR = 3.25 CI [2.1-5.1]pversusRCB-0: HR = 5.6 CI [3.5-8.9]p