Dickkopf-1 is a member of a new family of secreted proteins and functions in head induction
Dickkopf-1 is a member of a new family of secreted proteins and functions in head induction
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DOI：
10.1038/34848
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发表时间：
1998-01-22
期刊：
影响因子：
64.8
通讯作者：
Niehrs, C
中科院分区：
文献类型：
--
作者：
Glinka, A;Wu, W;Niehrs, C
两栖动物胚胎中的施佩曼组织者是一种具有强大头部诱导活性的组织，其分子本质尚未明确。在此我们描述 dickkopf - 1（dkk - 1），它编码Dkk - 1，一种在非洲爪蟾中施佩曼组织者的分泌性诱导因子，并且是一个新蛋白质家族的成员。mRNA和抗体注射表明dkk - 1对于引起头部诱导是充分且必要的。dkk - 1是Wnt信号传导的一种强效拮抗剂，这表明dkk基因编码一类分泌型Wnt抑制剂。
The Spemann organizer in amphibian embryos is a tissue with potent head-inducing activity, the molecular nature of which is unresolved. Here we describe dickkopf-1 (dkk-1), which encodes Dkk-1, a secreted inducer of Spemann's organizer in Xenopus and a member of a new protein family. Injections of mRNA and antibody Indicate that dkk-1 is sufficient and necessary to cause head induction. dkk-1 is a potent antagonist of Wnt signalling, suggesting that dkk genes encode a family of secreted Wnt inhibitors.