Spousal metabolic risk factors and incident hypertension: A longitudinal cohort study in Iran
Spousal metabolic risk factors and incident hypertension: A longitudinal cohort study in Iran
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DOI：
10.1111/jch.13783
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发表时间：
2019-12-31
影响因子：
2.8
通讯作者：
Hadaegh, Farzad
中科院分区：
文献类型：
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作者：
Ramezankhani, Azra;Guity, Kamran;Hadaegh, Farzad
我们调查了配偶一方与另一方高血压患者的代谢危险因素之间的关系。研究样本包括德黑兰血脂和血糖研究中年龄为20岁的1528名男性和1649名女性，他们的信息包括体重指数(BMI)、腰围(WC)、高血压、2型糖尿病(DM)和血脂异常。男性和女性中配偶代谢因素与高血压事件的风险比(HR)和95%可信区间(95%CI)分别被估计。共观察到604例男性和566例女性高血压。在男性中，在调整了男性自身及其配偶的风险因素(包括体重指数、糖尿病、吸烟和体力活动水平)后，配偶糖尿病与高血压的超额风险相关40%(CI：1.07-1.83)。在女性中，配偶糖尿病与高血压风险增加两倍以上(2.11，1.69-2.63)相关。在对女性自身及其配偶的风险因素进行进一步调整后，这种关联性减弱了，并保持了轻微的显著性(1.25，0.99-1.58；P值=0.053)。有一位患有糖尿病的配偶会增加个人患高血压的风险，这就增加了利用其中一方先前存在的信息来指导对另一方进行筛查的可能性。
We investigated the association between metabolic risk factors in one spouse with incident hypertension in the other. Study sample included 1528 men and 1649 women aged >= 20 years from the Tehran lipid and glucose study with information on body mass index (BMI), waist circumference (WC), hypertension, type 2 diabetes mellitus (DM), and dyslipidemia. The hazard ratio (HR) and 95% confidence interval (95% CI) were estimated for the association of spousal metabolic factors and incident hypertension among men and women separately. A total of 604 and 566 cases of incident hypertension were observed in men and women, respectively. Among men, spousal DM was associated with a 40% (CI: 1.07-1.83) excess risk of hypertension after adjusting for the men's own and their spouse's risk factors including BMI, DM, smoking, and physical activity level. Among women, spousal DM was associated with more than two times (2.11, 1.69-2.63) higher risk of hypertension. After further adjustment for the women's own and their spouse's risk factors, the association was attenuated and remained marginally significant (1.25, 0.99-1.58; P value = .053). Having a spouse with DM increases an individual's risk of hypertension, which raises the possibility of using preexisting information of one partner to guide the screening of the other partner.