β-catenin signaling in biological control and cancer
β-catenin signaling in biological control and cancer
复制标题
DOI：
10.1002/jcb.21505
复制
发表时间：
2007-11-01
影响因子：
4
通讯作者：
Ben-Ze'ev, Avri
中科院分区：
文献类型：
--
作者：
Gavert, Nancy;Ben-Ze'ev, Avri
细胞-细胞粘附和基因表达控制的协调整合对于多细胞分化生物体的发育至关重要。β-连环蛋白通过将钙粘蛋白粘附受体连接到细胞骨架，在细胞-细胞粘附中实现重要的调节功能，并且还作为Wnt信号传导途径中的关键元件，其中其作为细胞核中靶基因的共转录激活剂。Wnt信号转导参与胚胎发育的许多方面，并参与多种成体组织中组织自我更新的控制。Wnt信号的过度激活，主要是通过影响β-连环蛋白功能，是结肠癌和许多其他人类癌症的标志。在这个前景中，我们讨论的研究指出，管理细胞间粘附和基因表达之间的整合的分子机制，反映在这两个功能之间的开关P-连环蛋白在结肠癌细胞。
A coordinated integration of cell-cell adhesion and the control of gene expression is essential for the development of multicellular, differentiated organisms. beta-Catenin fulfils important regulatory functions in both cell-cell adhesion by linking cadherin adhesion receptors to the cytoskeleton, and also as a key element in the Wnt signaling pathway where it acts as cotranscriptional activator of target genes in the cell nucleus. Wnt signaling is involved in numerous aspects of embryonic development and in the control of tissue self-renewal in a variety of adult tissues. Hyperactivation of Wnt signaling, mostly by affecting beta-catenin functions, is a hallmark of colon cancerand of many other human cancers. In this prospect, we discuss studies pointing to the molecular mechanisms that govern the integration between cell-cell adhesion and gene expression, as reflected in the switches between these two functions of P-catenin in colon cancer cells.