Quasispecies of dengue virus.
Quasispecies of dengue virus.
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DOI：
10.2149/tmh.2011-s02
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发表时间：
2011-12-01
影响因子：
4.5
通讯作者：
Kurosu, Takeshi
中科院分区：
文献类型：
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作者：
Kurosu, Takeshi
致病病毒具有引起急性和慢性感染的RNA基因组。这些病毒以高突变率复制，并表现出显着的遗传多样性，所谓的病毒准种。病毒准种在慢性感染性疾病中起着重要作用，但其在急性感染性疾病如登革病毒（DENV）感染中的作用却知之甚少。登革病毒（DENV）是人类最重要的虫媒病毒，是登革热（DF）和登革出血热（DHF）的病原体。越来越多的观察表明，登革病毒作为一个极其多样化的病毒群体存在，但其生物学意义尚不清楚。在其他病毒性疾病中，准种会影响药物和疫苗的治疗策略。在这里，我描述了准种登革病毒和讨论准种的发病机制和治疗策略，对登革病毒感染的可能作用相比，与其他病毒，如丙型肝炎病毒，人类免疫缺陷病毒1型，脊髓灰质炎病毒。
Pathogenic viruses have RNA genomes that cause acute and chronic infections. These viruses replicate with high mutation rates and exhibit significant genetic diversity, so-called viral quasispecies. Viral quasispecies play an important role in chronic infectious diseases, but little is known about their involvement in acute infectious diseases such as dengue virus (DENV) infection. DENV, the most important human arbovirus, is a causative agent of dengue fever (DF) and dengue hemorrhagic fever (DHF). Accumulating observations suggest that DENV exists as an extremely diverse virus population, but its biological significance is unclear. In other virus diseases, quasispecies affect the therapeutic strategies using drugs and vaccines. Here, I describe the quasispecies of DENV and discuss the possible role of quasispecies in the pathogenesis of and therapeutic strategy against DENV infection in comparison with other viruses such as Hepatitis C virus, human immunodeficiency virus type 1, and poliovirus.