Mental state attribution, neurocognitive functioning, and psychopathology:: What predicts poor social competence in schizophrenia best?
Mental state attribution, neurocognitive functioning, and psychopathology:: What predicts poor social competence in schizophrenia best?
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DOI：
10.1016/j.schres.2007.01.006
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发表时间：
2007-05-01
影响因子：
4.5
通讯作者：
Sonntag, Claudia
中科院分区：
文献类型：
--
作者：
Bruene, Martin;Abdel-Hamid, Mona;Sonntag, Claudia
背景资料：对精神状态归因的研究一再表明，精神分裂症患者在反思自己和他人的信仰、知识和意图方面的能力受损，重要的困惑是执行功能、智力、疾病持续时间和药物治疗。此外，受损的精神状态归因，神经认知和精神病理学解释精神分裂症患者异常社会行为的程度一直是一个争论的问题。我们试图确定是否精神状态归因于精神分裂症的预测差的社会能力比“非社会”的认知因素或psychopathology.Methods：智力，执行功能，精神状态归因，精神病理学和社会行为进行了评估，38例精神分裂症患者根据DSM-IV标准，并与29名健康对照组年龄和性别。所有患者接受抗精神病药物治疗，所有参与者都没有药物滥用或创伤性脑injuries.Results的历史：在整个精神分裂症组受损的精神状态归因单独占偏差的社会行为的方差的50%左右，而PANSS阳性评分和病程贡献了额外的少量的方差。这种影响在智力至少正常的患者亚组中更为明显，PANSS评分和疾病的慢性程度都不是社交能力差的重要预测因素。药物治疗与任何一个神经认知措施，包括精神状态归因，精神病理学或社会behavior.Conclusions：能力受损，欣赏自己和他人的精神状态是单一的最好的预测精神分裂症的社会能力差，也许应该包括在未来的定义的“核心”精神分裂症的精神病学。(c)2007 Elsevier B. V.保留所有权利。
Background: Research into mental state attribution has repeatedly shown that patients with schizophrenia are impaired in their capacity to reflect upon their own and others' beliefs, knowledge and intentions, with important confounds being executive functioning, intelligence, duration of illness, and medication. Furthermore, the extent to which impaired mental state attribution, neurocognition and psychopathology explain abnormal social behavior in schizophrenic patients has been a matter of debate. We sought to determine whether mental state attribution in schizophrenia predicts poor social competence better than "non-social" cognitive factors or psychopathology.Methods: Intelligence, executive functioning, mental state attribution, psychopathology and social behavior were assessed in 38 patients diagnosed with schizophrenia according to DSM-IV criteria and compared with 29 healthy controls paralleled for age and sex. All patients received antipsychotic treatment, and all participants had no history of substance abuse or traumatic brain injury.Results: In the entire schizophrenia group impaired mental state attribution alone accounted for about 50% of the variance of deviant social behavior, whereas the PANSS positive score and the duration of illness contributed an additional small amount of variance. This effect was even more pronounced in a subgroup of patients with at least normal intelligence, where neither the PANSS score nor the chronicity of the disorder remained significant predictors of poor social competence. Medication was not associated with any one of the neurocognitive measures including mental state attribution, psychopathology or social behavior.Conclusions: Impaired capacity to appreciate one's own and others' mental states is the single-best predictor of poor social competence in schizophrenia, and should perhaps be included in future definitions of the "core" symptomatology of schizophrenic disorders. (c) 2007 Elsevier B.V. All rights reserved.