Evidence that RpoS (σS) in Borrelia burgdorferi Is Controlled Directly by RpoN (σ54/σN)
Evidence that RpoS (σS) in Borrelia burgdorferi Is Controlled Directly by RpoN (σ54/σN)
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DOI：
10.1128/jb.01653-06
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发表时间：
2006-12
影响因子：
3.2
通讯作者：
Alexandra H. Smith;J. Blevins;Gulnaz N. Bachlani;Xiaofeng F. Yang;M. Norgard
中科院分区：
文献类型：
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作者：
Alexandra H. Smith;J. Blevins;Gulnaz N. Bachlani;Xiaofeng F. Yang;M. Norgard
替代σ因子（RpoN-RpoS）途径控制伯氏疏螺旋体中关键毒力因子的表达。然而，证据来支持是否RPoN控制rpoS直接或间接通过反式激活蛋白一直缺乏。在此，我们提供了RpoN直接控制B中rpoS的生化和遗传证据。burgdorferi。
ABSTRACT The alternative sigma factor (RpoN-RpoS) pathway controls the expression of key virulence factors in Borrelia burgdorferi. However, evidence to support whether RpoN controls rpoS directly or, perhaps, indirectly via a transactivator has been lacking. Herein we provide biochemical and genetic evidence that RpoN directly controls rpoS in B. burgdorferi.