Interictal epileptiform discharges impair word recall in multiple brain areas.
Interictal epileptiform discharges impair word recall in multiple brain areas.
复制标题
作者：
Horak PC;Meisenhelter S;Song Y;Testorf ME;Kahana MJ;Viles WD;Bujarski KA;Connolly AC;Robbins AA;Sperling MR;Sharan AD;Worrell GA;Miller LR;Gross RE;Davis KA;Roberts DW;Lega B;Sheth SA;Zaghloul KA;Stein JM;Das SR;Rizzuto DS;Jobst BC
发作间期癫痫样放电（IED）与记忆障碍有关，但这种关系的空间和时间动力学仍然难以捉摸。在本研究中，我们的目标是系统地描述简易爆炸装置影响记忆的大脑区域和时间。80例癫痫患者在接受颅内脑电图监测时参加了延迟自由回忆任务。我们分析了简易爆炸装置相对于行为数据的位置和时间，以测量它们对记忆的影响。总体IED率与受试者的任务表现无关（r = 0.03，p = 0.8）。然而，在一个更精细的时间尺度上，在任务的编码和回忆阶段，被试内记忆受到IED的负面影响，但在休息和分心阶段则没有受到IED的负面影响（分别为p <0.01，p < 0.001，p = 0.3和p = 0.8）。IED对编码和回忆的影响在左半球强于右半球（p < 0.05）。在分析的六个脑区中，下颞区、内侧颞区和顶叶区的IED显著影响记忆（错误发现率< 0.05）。这些发现揭示了一个对简易爆炸装置敏感的大脑区域网络，其关键节点位于颞叶和顶叶。他们还证明了简易爆炸装置在这个网络中对记忆的时间依赖性影响。
Interictal epileptiform discharges (IEDs) have been linked to memory impairment, but the spatial and temporal dynamics of this relationship remain elusive. In the present study, we aim to systematically characterize the brain areas and times at which IEDs affect memory. Eighty epilepsy patients participated in a delayed free recall task while undergoing intracranial EEG monitoring. We analyzed the locations and timing of IEDs relative to the behavioral data in order to measure their effects on memory. Overall IED rates did not correlate with task performance across subjects (r = 0.03, p = 0.8). However, at a finer temporal scale, within-subject memory was negatively affected by IEDs during the encoding and recall periods of the task but not during the rest and distractor periods (p < 0.01, p < 0.001, p = 0.3, and p = 0.8 respectively). The effects of IEDs during encoding and recall were stronger in the left hemisphere than in the right (p < 0.05). Out of six brain areas analyzed, IEDs in the inferior temporal, medial temporal, and parietal areas significantly affected memory (false discovery rate < 0.05). These findings reveal a network of brain areas sensitive to IEDs with key nodes in temporal as well as parietal lobes. They also demonstrate the time-dependent effects of IEDs in this network on memory.