Molecular regulation of cardiomyocyte differentiation.
Molecular regulation of cardiomyocyte differentiation.
复制标题
DOI：
10.1161/circresaha.116.302752
复制
发表时间：
2015-01-16
影响因子：
20.1
通讯作者：
Wu SM
中科院分区：
文献类型：
--
作者：
Paige SL;Plonowska K;Xu A;Wu SM
心脏是胚胎发育过程中形成的第一个器官。鉴于心脏分化和形态发生的复杂性，大约1%的新生儿存在某种形式的先天性心脏病并不奇怪。心脏发育的分子决定因素在过去的几十年里受到了广泛的关注。这在很大程度上是由于对了解先天性心脏病病因的兴趣，以及利用发育生物学知识产生可用于再生医学目的的功能细胞和组织的潜力。在这篇综述中，我们强调了在体内和体外模型中调节心肌细胞谱系特化的关键信号通路和转录因子网络。将特别关注表观遗传调节剂，驱动新生中胚层的心肌细胞的承诺，并将其分化为室特异性肌细胞，以及心肌小梁形成的调节。
The heart is the first organ to form during embryonic development. Given the complex nature of cardiac differentiation and morphogenesis, it is not surprising that some form of congenital heart disease is present in approximately one percent of newborns. The molecular determinants of heart development have received much attention over the past several decades. This has been driven in large part by an interest in understanding the etiology of congenital heart disease coupled with the potential of utilizing knowledge from developmental biology to generate functional cells and tissues that could be used for regenerative medicine purposes. In this review, we highlight the critical signaling pathways and transcription factor networks that regulate cardiomyocyte lineage specification in both in vivo and in vitro models. Special focus will be given to epigenetic regulators that drive the commitment of cardiomyogenic cells from nascent mesoderm and their differentiation into chamber-specific myocytes as well as regulation of myocardial trabeculation.