Relation of high neuroticism with increased methylation of the BDNF gene.
Relation of high neuroticism with increased methylation of the BDNF gene.
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DOI：
10.2147/ndt.s169787
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发表时间：
2018
影响因子：
3.2
通讯作者：
Otani K
中科院分区：
文献类型：
--
作者：
Shirata T;Suzuki A;Matsumoto Y;Takahashi N;Noto K;Goto K;Otani K
脑源性神经营养因子（Brain-derived neurotrophic factor，BDNF）是一种神经营养因子，在神经可塑性和神经元发育中具有重要作用。这表明BDNF基因甲基化增加导致BDNF活性降低与抑郁症有关。同时，神经质是一个众所周知的抑郁症的危险因素。在本研究中，BDNF基因甲基化和人格特征，包括神经质之间的关系进行了检查。研究对象为98名健康日本人。BDNF基因的甲基化水平通过亚硫酸氢盐焦磷酸测序法测定。人格特质，包括神经质的NEO人格量表修订版进行评估。神经质得分与BDNF基因甲基化水平呈正相关。与神经质得分较低的受试者相比，神经质得分较高的受试者的BDNF基因甲基化水平较高。其他人格特征与BDNF基因甲基化无相关性。目前的研究表明，高神经质与BDNF基因甲基化增加有关。
Brain-derived neurotrophic factor (BDNF) is a neurotrophin that has an important function in neuroplasticity and neuronal development. It is suggested that increased methylation of the BDNF gene resulting in decreased BDNF activity is associated with depression. Meanwhile, neuroticism is a well-known risk factor for developing depression. In the present study, the relationship between methylation of the BDNF gene and personality traits including neuroticism was examined. The subjects were 98 healthy Japanese. Methylation levels of the BDNF gene were determined by the bisulfite-pyrosequencing method. Personality traits including neuroticism were assessed by the NEO Personality Inventory-Revised. There was a positive correlation between neuroticism scores and methylation levels of the BDNF gene. The subjects with higher neuroticism scores had higher levels of BDNF gene methylation compared with those with lower neuroticism scores. Meanwhile, other personality traits were not associated with BDNF gene methylation. The present study suggests that high neuroticism is related to increased methylation of the BDNF gene.