Enantioselective iridium-catalyzed carbonyl isoprenylation via alcohol-mediated hydrogen transfer.
Enantioselective iridium-catalyzed carbonyl isoprenylation via alcohol-mediated hydrogen transfer.
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DOI：
10.1039/c8cc09706b
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发表时间：
2019-01
影响因子：
4.9
通讯作者：
Minglin Xiang;Guoshun Luo;Yuankai Wang;M. Krische
中科院分区：
文献类型：
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作者：
Minglin Xiang;Guoshun Luo;Yuankai Wang;M. Krische
高对映选择性的Ir催化的羰基(2-乙烯基)烯丙化反应或“异戊二烯基化”反应分别由伯醇或醛反应物通过氢自动转移或异丙醇介导的还原偶联来实现。利用该方法实现了萜类天然产物(+)-异二烯醇和(+)-异二烯醇的不对称全合成。
Highly enantioselective iridium catalyzed carbonyl (2-vinyl)allylation or "isoprenylation" is achieved via hydrogen auto-transfer or 2-propanol-mediated reductive coupling from primary alcohol or aldehyde reactants, respectively. Using this method, asymmetric total syntheses of the terpenoid natural products (+)-ipsenol and (+)-ipsdienol were achieved.