Riboflavin to treat nucleoside analogue-induced lactic acidosis
Riboflavin to treat nucleoside analogue-induced lactic acidosis
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DOI：
10.1016/s0140-6736(05)60266-8
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发表时间：
1998-07-25
期刊：
影响因子：
168.9
通讯作者：
Reves, R
中科院分区：
文献类型：
--
作者：
Fouty, B;Frerman, F;Reves, R
艾滋病患者在服用齐多夫定1和去羟肌苷2等核苷逆转录酶抑制剂（NRTI）时出现乳酸酸中毒和肝脂肪变性NRTI抑制负责线粒体DNA合成的DNA聚合酶γ线粒体DNA合成的抑制已被提出是导致乳酸酸中毒和肝脂肪变性的机制我们认为肯定还有其他因素参与，因为，尽管这些药物对DNA聚合酶γ的影响是可预测的，但乳酸酸中毒并不常见，因为我们和其他人1，2已经观察到乳酸酸中毒在停用NRTI后不容易逆转。
Patients with AIDS have developed lactic acidosis and hepatic steatosis while taking nucleoside reverse-transcriptase inhibitors (NRTI) such as zidovudine 1 and didanosine 2 NRTIs inhibit DNApolymerase γ, responsible for mitochondrial DNA synthesis Inhibition of mitochondrial DNA synthesis has been proposed as the mechanism responsible for lactic acidosis and hepatic steatosis We considered that there must be other factors involved because, despite the predictable effects of these agents on DNA polymerase γ, lactic acidosis is uncommon, and because we and others 1, 2 have observed that lactic acidosis is not readily reversible after discontinuation of NRTI.