Dissimilar Fitness Associated with Resistance to Fluoroquinolones Influences Clonal Dynamics of Various Multiresistant Bacteria.
Dissimilar Fitness Associated with Resistance to Fluoroquinolones Influences Clonal Dynamics of Various Multiresistant Bacteria.
复制标题
与氟喹诺酮类抗性相关的不同适应性会影响各种多耐药细菌的克隆动力学。
DOI：
10.3389/fmicb.2016.01017
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发表时间：
2016
影响因子：
5.2
通讯作者：
Fuzi M
中科院分区：
文献类型：
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作者：
Fuzi M
最近研究表明，耐甲氧西林金黄色葡萄球菌和产超广谱β-内酰胺酶肺炎克雷伯菌的克隆体之间，与氟喹诺酮类耐药相关的适应性成本存在差异。由此产生的不同的健身应影响克隆动态，从而对这些病原体的抗性率。此外，最近提出了一个类似的机制，出现H30和H30 R谱系的ESBL产生的E。大肠杆菌和艰难梭菌的主要国际克隆（核糖体型027）。此外，怀疑多种多重耐药细菌的几个额外的国际克隆是通过类似的过程选择的。在促旋酶和拓扑异构酶IV基因中发展有利突变的能力似乎是病原体保持适应性同时显示对氟喹诺酮类药物的高水平耐药性的先决条件。由于其他“非氟喹诺酮类”抗生素的消费也导致了耐药率的上升，因此更明智地使用抗生素，特别是氟喹诺酮类抗生素，可以改善国际耐药状况。
Fitness cost associated with resistance to fluoroquinolones was recently shown to vary across clones of methicillin-resistant Staphylococcus aureus and extended-spectrum β-lactamase-producing Klebsiella pneumoniae. The resulting dissimilar fitness should have influenced the clonal dynamics and thereby the rates of resistance for these pathogens. Moreover, a similar mechanism was recently proposed for the emergence of the H30 and H30R lineages of ESBL-producing E. coli and the major international clone (ribotype 027) of Clostridium difficile. Furthermore, several additional international clones of various multiresistant bacteria are suspect to have been selected by an analogous process. An ability to develop favorable mutations in the gyrase and topoisomerase IV genes seems to be a prerequisite for pathogens to retain fitness while showing high-level resistance to fluoroquinolones. Since, the consumption of other “non-fluoroquinolone” groups of antibiotics have also contributed to the rise in resistance rates a more judicious use of antibiotics in general and of fluoroquinolones in particular could ameliorate the international resistance situation.