Non-decay type fast-setting calcium phosphate cement: Setting behaviour in calf serum and its tissue response
Non-decay type fast-setting calcium phosphate cement: Setting behaviour in calf serum and its tissue response
复制标题
DOI：
10.1016/0142-9612(96)87286-3
复制
发表时间：
1996-07-01
期刊：
影响因子：
14
通讯作者：
Asaoka, K
中科院分区：
文献类型：
--
作者：
Miyamato, Y;Ishikawa, K;Asaoka, K
非腐烂型快速凝固磷酸钙水泥（nd-FSCPC）在犊牛血清中的凝固行为及其组织反应进行了评估，以探讨其在外科应用中临床应用的可行性。通过在碱性水泥、快凝磷酸钙水泥（FSCPC）和常规磷酸钙水泥（c-CPC）的液相中加入不同量的海藻酸钠，制备了不腐型水泥。混合后立即将水泥浆浸泡在37℃的血清中，测量其衰变行为、凝固时间和机械强度，以评估其在外科应用中的可能性。此外，将nd-FSCPC植入大鼠皮下组织，初步评估这种潜在生物活性水泥的生物相容性。即使在混合后立即将水泥浆浸入血清中，nd-FSCPC在血清中也会在大约6-7分钟内凝固，而c-CPC和FSCPC在浸入后完全腐烂。nd-FSCPC在24 h内转变为羟基磷灰石（HA），其直径抗拉强度约为4-5 MPa。nd-FSCPC经转化为HA后，在大鼠皮下移植后表现出良好的组织反应。我们得出结论，nd-FSCPC在骨水泥暴露于血液的骨科、整形和重建外科以及口腔颌面外科中具有良好的潜在价值。(C) 1996 Elsevier Science Limited
Non-decay type fast-setting calcium phosphate cement (nd-FSCPC) was evaluated in terms of its setting behaviour in calf serum and its tissue response to investigate the feasibility of its clinical use in surgical applications. Non-decay type cements were prepared by adding various amounts of sodium alginate to the liquid phase of base cements, fast-setting calcium phosphate cement (FSCPC) and conventional calcium phosphate cement (c-CPC). Cement pastes were immersed in serum at 37 degrees C immediately after mixing, and decay behaviour, setting time and mechanical strength were measured to evaluate the possibility of their use in surgical applications. Also, nd-FSCPC was implanted into rat subcutaneous tissue for the initial evaluation of biocompatibility of this potential bioactive cement. nd-FSCPC set in approximately 6-7 min in serum, even when the cement paste was immersed in the serum immediately after mixing, whereas c-CPC and FSCPC decayed completely upon immersion. nd-FSCPC transforms to hydroxyapatite (HA) within 24 h and shows a diametral tensile strength of approximately 4-5 MPa. As a result of transformation to HA, nd-FSCPC showed excellent tissue response when implanted subcutaneously in rats. We conclude that nd-FSCPC has good potential value for use in orthopaedics, plastic and reconstructive surgery, and oral and maxillofacial surgery, where the cement is exposed to blood. (C) 1996 Elsevier Science Limited