EFFECT OF A HIGH-FREQUENCY VIBRATION BOUNDARY ON RBC
EFFECT OF A HIGH-FREQUENCY VIBRATION BOUNDARY ON RBC
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DOI：
10.1142/s0219519418400328
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发表时间：
2018-12
影响因子：
0.8
通讯作者：
Zhong Yun;Chuang Xiang;Liang Wang
中科院分区：
文献类型：
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作者：
Zhong Yun;Chuang Xiang;Liang Wang
在实际应用中，血泵中的振动常由高速运转、悬浮结构、黏弹性植入环境等因素引起。采用非线性弹簧网络模型对红细胞（RBC）进行建模。运用浸入边界 - 格子玻尔兹曼方法（IB - LBM）研究高频振动边界对红细胞的影响。为验证红细胞模型，将红细胞拉伸的模拟结果与实验结果进行了对比。我们考察了作用于红细胞膜节点的力；此外，还确定了红细胞能量是否受边界不同频率、振幅及振动模式的影响。进一步地，我们研究了红细胞能量是否受上下边界间距的影响。同时也对受振动边界干扰的剪切流中红细胞的能量进行了探究。结果表明，更大的振幅（Am）、频率（Fr）以及上下边界相反的振动速度，会使作用于红细胞膜节点的力更大，且红细胞的能量变化也更大。振动边界可能引发湍流并改变红细胞能量。在设计和优化血泵时，应降低血泵主体和叶轮的振动频率与振幅，使血泵主体和叶轮振动速度的相位相近。为减轻红细胞的自由能并减少血泵中红细胞的损伤，红细胞与边界的距离不应小于20[公式：见正文][公式：见正文]微米。
The vibrations in blood pumps were often caused by high speed, suspension structure, viscoelastic implantation environment and other factors in practical application. Red blood cell (RBC) was modeled using a nonlinear spring network model. The immersed boundary-lattice Boltzmann method (IB-LBM) was used to investigate the impact of high-frequency vibration boundary on RBC. To confirm the RBC model, the simulation results of RBC stretching were compared with experimental results. We examined the force acting on RBC membrane nodes; moreover, we determined whether RBC energy was affected by different frequencies, amplitudes, and vibration models of the boundary. Furthermore, we examined whether RBC energy was affected by the distance between the top and bottom boundaries. The energy of RBCs in shear flow disturbed by the vibration boundary was also investigated. The results indicate that larger amplitude (Am), frequency (Fr), and opposite vibration velocity of top and bottom boundary produced a larger force that acted on RBC membrane nodes and larger energy changes in RBCs. The vibration boundary may cause turbulence and alter RBC energy. When the blood pump was designed and optimized, the vibration frequency and amplitude of the blood pump body and impeller should be reduced, the phase of the blood pump body and impeller vibration velocity should be close. To alleviate the free energy of RBCs and to reduce RBC injury in the blood pump, the distance between RBCs and the boundary should not be less than 20[Formula: see text][Formula: see text]m.