ILC2s and Adipose Tissue Homeostasis: Progress to Date and the Road Ahead.
ILC2s and Adipose Tissue Homeostasis: Progress to Date and the Road Ahead.
复制标题
DOI：
10.3389/fimmu.2022.876029
复制
发表时间：
2022
影响因子：
7.3
通讯作者：
中科院分区：
文献类型：
--
作者：
2组先天淋巴样细胞（ILC2s）最初被确定为一种在脂肪组织中产生大量2型细胞因子的新型淋巴细胞。随后的研究表明，ILC2s不仅存在于脂肪组织中，还存在于肺和皮肤等其他组织中。ILC2s通常被认为是调节组织稳态的组织驻留免疫细胞。ILC2s表达多种体液因子的受体，因此可以根据环境和情况改变其功能或分布。在这篇综述中，我们将概述我们最近对ILC2生物学的理解，并讨论ILC2研究的未来方向，特别是在脂肪组织和代谢稳态方面。
Group 2 innate lymphoid cells (ILC2s) were initially identified as a new type of lymphocytes that produce vigorous amounts of type 2 cytokines in adipose tissue. Subsequent studies revealed that ILC2s are present not only in adipose tissue but also in various other tissues such as lung and skin. ILC2s are generally recognized as tissue-resident immune cells that regulate tissue homeostasis. ILC2s express receptors for various humoral factors and thus can change their functions or distribution depending on the environment and circumstances. In this review, we will outline our recent understanding of ILC2 biology and discuss future directions for ILC2 research, particularly in adipose tissue and metabolic homeostasis.