Paraspeckles
Paraspeckles
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DOI：
10.1101/cshperspect.a000687
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发表时间：
2010-07-01
影响因子：
7.2
通讯作者：
Lamond, Angus I.
中科院分区：
文献类型：
--
作者：
Fox, Archa H.;Lamond, Angus I.
副斑点是在哺乳动物细胞的染色质间隙中发现的一类相对较新的亚核体。它们是由长的非蛋白质编码RNA种类NEAT 1/Men β/beta和DBHS（果蝇行为人类剪接）蛋白质家族成员P54 NRB/NONO、PSPC 1和PSF/SFPQ之间的相互作用形成的RNA-蛋白质结构。旁斑对于通过RNA的核保留来控制基因表达是至关重要的，所述RNA含有已经受腺苷至肌苷编辑的双链RNA区域。通过这种机制，旁斑及其组分可能最终在许多细胞过程中控制基因表达，包括分化，病毒感染和应激反应。
Paraspeckles are a relatively new class of subnuclear bodies found in the interchromatin space of mammalian cells. They are RNA-protein structures formed by the interaction between a long nonprotein-coding RNA species, NEAT1/Men epsilon/beta, and members of the DBHS (Drosophila Behavior Human Splicing) family of proteins: P54NRB/NONO, PSPC1, and PSF/SFPQ. Paraspeckles are critical to the control of gene expression through the nuclear retention of RNA containing double-stranded RNA regions that have been subject to adenosine-to-inosine editing. Through this mechanism paraspeckles and their components may ultimately have a role in controlling gene expression during many cellular processes including differentiation, viral infection, and stress responses.