Multiscale polar theory of microtubule and motor-protein assemblies.
Multiscale polar theory of microtubule and motor-protein assemblies.
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DOI：
10.1103/physrevlett.114.048101
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发表时间：
2015-01-30
影响因子：
8.6
通讯作者：
Shelley MJ
中科院分区：
文献类型：
--
作者：
Gao T;Blackwell R;Glaser MA;Betterton MD;Shelley MJ
微管和马达蛋白是自组织亚细胞生物结构（例如有丝分裂纺锤体和中心体微管阵列）的基石。这些相同的成分可以形成新的“生物活性”液晶流体，其本质上是不平衡的，并且显示出复杂的流动和缺陷动力学。目前还没有很好地理解微观活动，其中涉及马达蛋白和微管之间的极性依赖性相互作用，产生这样的大尺度动力学结构。在我们的多尺度理论中，布朗动力学模拟由交联马达驱动的极性微管集合，使我们能够研究微观组织和应力。极性分选和交联松弛作为两个极性特定的主动不稳定应力的来源出现。在更大的长度尺度上，我们的连续体Doi-Onsager理论捕获了由极性相关的主动应力产生的流体动力学流动。结果连接局部极性结构的流动结构和缺陷动力学。
Microtubules and motor proteins are building blocks of self-organized subcellular biological structures such as the mitotic spindle and the centrosomal microtubule array. These same ingredients can form new “bioactive” liquid-crystalline fluids that are intrinsically out of equilibrium and which display complex flows and defect dynamics. It is not yet well understood how microscopic activity, which involves polarity-dependent interactions between motor proteins and microtubules, yields such larger-scale dynamical structures. In our multiscale theory, Brownian dynamics simulations of polar microtubule ensembles driven by cross-linking motors allow us to study microscopic organization and stresses. Polarity sorting and cross-link relaxation emerge as two polar-specific sources of active destabilizing stress. On larger length scales, our continuum Doi-Onsager theory captures the hydrodynamic flows generated by polarity-dependent active stresses. The results connect local polar structure to flow structures and defect dynamics.