Multicentric occurrence of hepatocellular carcinoma in patients with a somatic mutation of mitochondorial DNA and hepatitis C virus
Multicentric occurrence of hepatocellular carcinoma in patients with a somatic mutation of mitochondorial DNA and hepatitis C virus
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DOI：
10.1016/s1386-6346(02)00150-x
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发表时间：
2003-01-01
影响因子：
4.2
通讯作者：
Nishiguchi, S
中科院分区：
文献类型：
--
作者：
Kubo, S;Nishikawa, M;Nishiguchi, S
探讨丙型肝炎病毒感染患者非癌性肝组织线粒体DNA （mtDNA）突变频率与肝细胞癌（HCC）多中心发生的关系。在48例患者中，33例mtDNA有3个或更多突变的患者中有10例发生多中心HCC，而在15例mtDNA有2个或更少突变的患者中没有患者发生多中心HCC （P = 0.0201）。非癌性肝组织中mtDNA的高突变率可能与此类患者的多中心肝癌发生和高致癌状态有关。(C) 2002 Elsevier Science B.V.版权所有
The relationship between the multicentric occurrence of hepatocellular carcinoma (HCC) and the frequency of mutation of mitochondrial DNA (mtDNA) in the noncancerous hepatic tissue in patients infected with hepatitis C virus was investigated. Of the 48 patients, multicentric occurrence of HCC was found in ten of 33 patients with three or more mutations in the mtDNA, whereas no patients had multicentric HCCs in 15 patients with two or fewer mutations in the mtDNA (P = 0.0201). A high rate of mtDNA mutation in noncancerous hepatic tissue may be related to multicentric hepatocarcinogenesis and the hypercarcinogenic state in such patients. (C) 2002 Elsevier Science B.V. All rights reserved.