Diet-induced inflammation is associated with sarcopenia and muscle strength in older adults who visit a frailty clinic
Diet-induced inflammation is associated with sarcopenia and muscle strength in older adults who visit a frailty clinic
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DOI：
10.1007/s40520-022-02195-9
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发表时间：
2022-07-16
影响因子：
4
通讯作者：
Maeda, Keisuke
中科院分区：
文献类型：
--
作者：
Inoue, Tatsuro;Shimizu, Akio;Maeda, Keisuke
饮食引起的炎症可能与肌肉减少症有关;然而，很少有报道研究这种关系。目的研究日本一家虚弱诊所就诊的老年人饮食炎症指数（DII）与肌肉减少症之间的关系。方法本横断面研究使用了虚弱登记研究的门诊数据。DII是饮食诱导炎症的指数，使用简短的自我管理饮食史问卷进行饮食评估，以计算DII评分。我们按四分位数（Q1-Q4）对DII评分进行分类，并根据2019年亚洲肌肉减少症工作组共识诊断肌肉减少症。对肌肉减少症进行Logistic回归分析。年龄、性别、合并症和体力活动作为混杂因素输入（模型1），模型2、3和4将BMI、蛋白质摄入量和能量摄入量添加到模型1中。结果我们纳入了304例患者（平均年龄77.6 ± 6.3岁;女性，67.4%）。肌肉减少症的患病率为14.5%。逻辑回归分析显示，在模型1和2中，DII评分与肌肉减少症显著相关（模型1，参考：Q1，Q4：OR 3.10，P = 0.020;模型2，Q4：OR 3.40，P = 0.022），但在模型3和4中不相关。讨论饮食诱导的炎症与肌肉减少症的可能性较高相关;然而，在蛋白质和能量摄入混杂后，这种相关性消失。结论膳食蛋白质和能量参数是内科患者肌肉健康的主要驱动因素。
Background Diet-induced inflammation may be associated with sarcopenia; however, few reports have examined this relationship. Aim To examine the association between the dietary inflammatory index (DII) and sarcopenia in older adults who visited a frailty clinic in Japan. Methods This cross-sectional study used outpatient data from the Frailty Registry Study. The DII is an index of diet-induced inflammation, and a dietary assessment was performed using a brief self-administered diet history questionnaire to calculate the DII score. We classified DII scores by quartiles (Q1-Q4), and sarcopenia was diagnosed according to the Asian Working Group for Sarcopenia 2019 consensus. Logistic regression analyses for sarcopenia were performed. Age, sex, comorbidities, and physical activity were entered as confounding factors (Model 1) and Models 2, 3, and 4 with BMI, protein intake, and energy intake added to Model 1. Results We included 304 patients in the analysis (mean age, 77.6 +/- 6.3 years; female, 67.4%). The prevalence of sarcopenia was 14.5%. Logistic regression analyses showed that DII scores were significantly associated with sarcopenia in Model 1 and 2 (Model 1, reference: Q1, Q4: OR 3.10, P = 0.020; Model 2, Q4: OR 3.40, P = 0,022) but not in Model 3 and 4. Discussion Diet-induced inflammation is associated with a higher likelihood of sarcopenia; however, this association disappeared after confounding for protein and energy intake. Conclusions The results demonstrated that dietary protein and energy parameters were the main drivers for muscle health in medical patients.