The Sunnybrook stroke study - A prospective study of depressive symptoms and functional outcome
The Sunnybrook stroke study - A prospective study of depressive symptoms and functional outcome
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DOI：
10.1161/01.str.29.3.618
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发表时间：
1998-03-01
期刊：
影响因子：
8.3
通讯作者：
Szalai, JP
中科院分区：
文献类型：
--
作者：
Herrmann, N;Black, SE;Szalai, JP
背景与目的：为了评估抑郁症状的患病率、临床相关性以及抑郁症状对脑卒中康复的影响，我们对一组相对未选择但诊断良好的连续脑卒中幸存者进行了前瞻性随访。方法：符合世界卫生组织和国家神经疾病和中风研究所中风标准的连续入院的区域中风中心的患者符合条件。排除蛛网膜下腔出血和脑干中风。患者入院时接受CT、单光子发射CT和标准化的神经和认知检查。在脑卒中后3个月和1年，分别用Montgomery Asberg抑郁评定量表（MADRS）和Zung抑郁自评量表（SDS）评估抑郁症状。功能结果用功能独立性量表测量，残疾用牛津残疾量表评估。结果：我们在入组时评估了436例患者（平均+/-SD年龄，74.9+/-11.6岁）。有150名患者在3个月时可进行评估，136名患者在1年时可进行评估。在3个月时，有22% （SDS）至27% （MADRS）的人有明显的抑郁症状，在1年时，有21% （SDS）至22% （MADRS）。有明显抑郁症状的患者有更多的神经损伤(P
Background and Purpose-To assess the prevalence of depressive symptoms, their clinical correlates, and the effects of depressive symptoms on stroke recovery, a relatively unselected, well-diagnosed cohort of consecutive stroke survivors was followed prospectively.Methods-Consecutive admissions to a regional stroke center who met World Health Organization and National Institute of Neurological Disorders and Stroke criteria for stroke were eligible. Subarachnoid hemorrhage and brain stem strokes were excluded. Patients underwent CT, single-photon emission CT, and standardized neurological and cognitive examinations at entry. At 3 months and 1 year after stroke, depressive symptoms were assessed with the Montgomery Asberg Depression Rating Scale (MADRS) and the Zung Self-Rating Depression Scale (SDS). Functional outcome was measured with the Functional Independence Measure, and handicap was assessed by the Oxford Handicap Scale.Results-We assessed 436 patients at entry (mean+/-SD age, 74.9+/-11.6 years). There were 150 patients available for assessment at 3 months and 136 at 1 year. Marked depressive symptoms were noted in 22% (SDS) to 27% (MADRS) at 3 months and 21% (SDS) to 22% (MADRS) at 1 year. Patterns with marked depressive symptoms had more neurological impairment (P