Association between DNA content and tumor suppressor gene expression and aggressiveness of atypical teratoid/rhabdoid tumors
Association between DNA content and tumor suppressor gene expression and aggressiveness of atypical teratoid/rhabdoid tumors
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DOI：
10.1007/s00381-002-0633-9
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发表时间：
2002-10-01
影响因子：
1.4
通讯作者：
Langford, LA
中科院分区：
文献类型：
--
作者：
Berrak, SG;Özek, MM;Langford, LA
Objects: Atypical teratoid/rhabdoid tumors (AT/RT) are aggressive neoplasms that afflict infants and young children. The objective of this retrospective study was to determine the association between DNA content (DNA ploidy, cell cycle analysis), tumor suppressor gene (p53, pRb, p16, and MMAC/PTEN) expression and the biologic aggressiveness of these tumors. Methods: Eight tumors from 7 patients (1 girl, 6 boys; median age 4+/-6.7 months) were studied. Two patients had DNA aneuploidy and 5 patients manifested diploid DNA content at diagnosis. The proliferative index of the tumors ranged from 10% to 28% (median, 12+/-6.4%). The single tumor with a low proliferative index (i.e.,
