Synthesis of naphthalenes through three-component coupling of alkynes, Fischer carbene complexes, and benzaldehyde hydrazones via isoindole intermediates
Synthesis of naphthalenes through three-component coupling of alkynes, Fischer carbene complexes, and benzaldehyde hydrazones via isoindole intermediates
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DOI：
10.1021/ol800242n
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发表时间：
2008-04-17
期刊：
影响因子：
5.2
通讯作者：
Herndon, James W.
中科院分区：
文献类型：
--
作者：
Duan, Shaofeng;Sinha-Mahapatra, Dilip K.;Herndon, James W.
研究了2-炔基苯甲醛腙与碳配合物和缺电子炔三组分偶联合成萘衍生物的方法。该反应包括异吲哚衍生物的形成，接着是分子内diols - alder反应，然后是亚硝基挤出。使用不对称炔的反应具有高度的区域选择性。
The synthesis of naphthalene derivatives through three-component coupling of 2-alkynylbenzaidehyde hydrazones with carbene complexes and electron-deficient alkynes has been examined. The reaction involves formation of an isoindole derivative, followed by intramolecular Diels-Alder reaction, followed by nitrene extrusion. The reaction was highly regioselective using unsymmetrical alkynes.