Stabilization of amorphous indomethacin by co-grinding in a ternary mixture.
Stabilization of amorphous indomethacin by co-grinding in a ternary mixture.
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通过在三元混合物中共研磨来稳定无定形吲哚美辛。
DOI：
10.1016/s0378-5173(02)00196-5
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发表时间：
2002
影响因子：
5.8
通讯作者：
M. Senna
中科院分区：
文献类型：
--
作者：
Tomoyuki Watanabe;I. Ohno;N. Wakiyama;A. Kusai;M. Senna
用二氧化硅、滑石粉和氢氧化镁-二氧化硅混合物研磨可显著促进吲哚美辛(IM)的机械力化学非晶化。机械力化学非晶化速率的大小顺序为：Mg(OH)2-SiO_2混合物>；滑石&SiO_2。在30℃、相对湿度为11%的条件下，通过结晶行为考察了IM与载体复合的非晶态稳定性。从载体的机械诱导强酸性中心的角度解释了二元混合物作为载体的优越性。
Mechanochemical amorphization of indomethacin (IM) was substantially enhanced by grinding with SiO2, talc and a Mg(OH)2–SiO2mixture. The rates of the mechanochemical amorphization were in the order of Mg(OH)2–SiO2mixture>talc>SiO2. Amorphous state stability of IM compounded with the carrier was examined by crystallization behavior under the condition of 30°C and 11% relative humidity. Superiority of the binary mixture as a carrier was explained in terms of the mechanically induced strong acidic sites of the carrier.