Osteopontin as potential biomarker and therapeutic target in gastric and liver cancers
Osteopontin as potential biomarker and therapeutic target in gastric and liver cancers
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DOI：
10.3748/wjg.v18.i30.3923
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发表时间：
2012-08-14
影响因子：
4.3
通讯作者：
Luk, John M.
中科院分区：
文献类型：
--
作者：
Cao, Dong-Xing;Li, Zhi-Jie;Luk, John M.
胃癌和肝癌是世界范围内最常见的恶性肿瘤之一，也是导致死亡的主要原因，这是由于发现晚和复发率高。今天，这些癌症有着沉重的社会经济负担，因此有必要充分了解其病理生理学特征，以寻找有前途的生物标志物和治疗靶点。骨桥蛋白（OPN）在大多数胃癌和肝癌患者中过表达。在过去的十年中，新出现的证据表明，OPN水平与胃癌和肝癌的临床病理特征和预后相关，表明其可能作为此类患者的独立预后指标。功能研究已经证实了OPN敲低作为体外和体内治疗方法的潜力。此外，OPN在癌细胞和肿瘤微环境之间的相互作用中介导多方面的作用，其中许多细节需要进一步探索。OPN信号传导导致多种功能，包括预防细胞凋亡、调节血管生成、肿瘤相关巨噬细胞的功能障碍、细胞外基质的降解、磷酸肌醇3-激酶-Akt和核因子-κ B途径的激活，其导致肿瘤形成和进展，特别是在胃癌和肝癌中。这篇社论的目的是审查最近的研究结果，改变骨桥蛋白的表达和它的临床病理学与肿瘤进展，其作为一个治疗靶点的潜力，以及在胃癌和肝癌的推定机制。更好地了解骨桥蛋白在肿瘤发生中的意义可能有助于开发治疗方案，使这些致命的恶性肿瘤患者受益。(C)2012年百世登。All rights reserved.
Gastric cancer and liver cancer are among the most common malignancies and the leading causes of death worldwide, due to late detection and high recurrence rates. Today, these cancers have a heavy socioeconomic burden, for which a full understanding of their pathophysiological features is warranted to search for promising biomarkers and therapeutic targets. Osteopontin (OPN) is overexpressed in most patients with gastric and liver cancers. Over the past decade, emerging evidence has revealed a correlation of OPN level and clinicopathological features and prognosis in gastric and liver cancers, indicating its potential as an independent prognostic indicator in such patients. Functional studies have verified the potential of OPN knockdown as a therapeutic approach in vitro and in vivo. Furthermore, OPN mediates multifaceted roles in the interaction between cancer cells and the tumor microenvironment, in which many details need further exploration. OPN signaling results in various functions, including prevention of apoptosis, modulation of angiogenesis, malfunction of tumor-associated macrophages, degradation of extracellular matrix, activation of phosphoinositide 3-kinase-Akt and nuclear factor-kappa B pathways, which lead to tumor formation and progression, particularly in gastric and liver cancers. This editorial aims to review recent findings on alteration in OPN expression and its clinicopathological associations with tumor progression, its potential as a therapeutic target, and putative mechanisms in gastric and liver cancers. Better understanding of the implications of OPN in tumorigenesis might facilitate development of therapeutic regimens to benefit patients with these deadly malignancies. (C) 2012 Baishideng. All rights reserved.