An efficient synthesis of ferumoxytol induced by alternating-current magnetic field
An efficient synthesis of ferumoxytol induced by alternating-current magnetic field
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交流磁场诱导菲鲁莫托的高效合成
DOI：
10.1016/j.matlet.2016.02.006
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发表时间：
2016-05-01
影响因子：
3
通讯作者：
Gu, Ning
中科院分区：
文献类型：
--
作者：
Chen, Bo;Li, Yang;Gu, Ning
Ferumoxytol（Feraheme（TM））作为一种磁性纳米颗粒（MNPs），在美国获批临床应用，广泛用作肿瘤和炎症的磁共振成像（MRI）试剂，用于临床前诊断研究。在这项研究中，我们探索了一种由交流磁场（ACMF）诱导的菲鲁莫托的新合成方法。通过透射电子显微镜 (TEM)、粒度分析仪、傅里叶变换红外光谱仪 (FT-IR)、X 射线衍射 (XRD)、振动样品磁力计 (VSM) 和 ACMF 加热测量对制备的菲鲁莫托进行了表征。相关表征表明，合成的ferumoxytol在粒径分布、结晶度和磁性方面均优于普通化学共沉淀法制备的Feraheme(TM)。最重要的是，这种 ACMF 诱导的合成可能为阿莫西托的制备提供更好的策略。 (C) 2016 Elsevier B.V. 保留所有权利。
Ferumoxytol (Feraheme (TM)), as one kind of magnetic nanoparticles (MNPs), was approved for clinical application in USA and widely used as magnetic resonance imaging (MRI) agent in tumor and inflammation for preclinical diagnosis research. In this study, we explored a novel synthesis of ferumoxytol induced by alternating-current magnetic field (ACMF). As-prepared ferumoxytol was characterized by transmission electron microscopy (TEM), particle size analyzer, fourier transform infrared spectrometer (FT-IR), X-ray diffraction (XRD), vibrating sample magnetometer (VSM) and heating measurement in ACMF. Relative characterizations proved that as-synthesized ferumoxytol demonstrated better quality than Feraheme (TM) that was prepared by ordinary chemical co-precipitation on particle size distribution, crystallinity and magnetism. Above all, this ACMF induced synthesis may offer a better strategy for ferumoxytol preparation. (C) 2016 Elsevier B.V. All rights reserved.