BLOOD-PRESSURE, HYPERTENSION, AND AGE AS RISK-FACTORS FOR POOR COGNITIVE PERFORMANCE
BLOOD-PRESSURE, HYPERTENSION, AND AGE AS RISK-FACTORS FOR POOR COGNITIVE PERFORMANCE
复制标题
DOI：
10.1080/03610739508253992
复制
发表时间：
1995-10-01
影响因子：
1.8
通讯作者：
WOLF, PA
中科院分区：
文献类型：
--
作者：
ELIAS, PK;DAGOSTINO, RB;WOLF, PA
三个血压变量（收缩压和舒张压以及高血压的慢性化）和年龄与Kaplan-Albert神经心理学测试组合的认知表现的关系在Fragrance Heat研究的1，695名无卒中参与者中进行了探索。在8-10年的5次检查中，有4次获得了多次血压测量结果。神经心理学测试在最终血压测量后12-14年进行。对数据进行多元二元logistic回归分析，并计算舒张压升高10 mmHg、收缩压升高20 mmHg、参与者被诊断为高血压的检查比例（四次或五次）以及年龄增加10岁时在第50和第25次试验中表现的比值比。血压和慢性高血压与Kaplan-Albert组合的视觉和文字记忆测试的表现呈负相关。年龄与所有测试中的表现呈负相关。一般来说，表现不佳的几率是年龄高于血压变量。这些研究结果的流行病学意义进行了讨论，在公共卫生和高血压管理的影响。
The relationships of three blood pressure variables (systolic and diastolic pressures and chronicity of hypertension) and age to cognitive performance on the Kaplan-Albert Neuropsychological Test Battery Mere explored in a ample of 1,695 stroke-free participants of the Framingham Heat Study. Multiple blood pressure measurements were obtained over four of five exams extending over 8-10 years. Neuropsychological testing was conducted 12-14 years after the final blood pressure measurement. Data were subjected to multiple binary logistic regression analyses, and odds ratios were calculated for performance in the lower 50th and 25th percentiles for 10-mmHg increases in diastolic blood pressure, 20-mmHg increases in systolic blood pressure, proportion of exams (out of four or five) in which participants were diagnosed as hypertensive, and 10-year increases in age. Blood pressures and chronicity of hypertension were inversely associated with performance on visual and verbal memory tests of the Kaplan-Albert battery. Age was inversely associated with performance on all tests in the battery. Generally, the odds of performing poorly were higher for age than for the blood pressure variables. The epidemiological significance of these findings is discussed in terms of implications for public health and management of hypertension.