Assessment of voiding dysfunction in Parkinson's disease by the international prostate symptom score
Assessment of voiding dysfunction in Parkinson's disease by the international prostate symptom score
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DOI：
10.1136/jnnp.68.4.429
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发表时间：
2000-04-01
影响因子：
11
通讯作者：
Kuno, S
中科院分区：
文献类型：
--
作者：
Araki, I;Kuno, S
目的为了解帕金森病患者排尿功能障碍的发生率，并探讨排尿功能障碍与帕金森病各项指标（病情严重程度、病程、年龄、性别、抗帕金森药物治疗）的关系，在非选择（连续）抽样的患者中定量估计排尿功能障碍的存在。方法：采用国际前列腺症状评分，对1个月内就诊的帕金森病患者进行下尿路症状定量评估。结果：203例完成问卷调查的患者中，55例（27%）被认为有症状性排尿功能障碍。这些患者的下尿路症状程度与疾病的严重程度密切相关，而与病程或年龄无关。33例（16%）患者仅存在刺激性症状，3例（1.5%）患者仅存在阻塞性症状。13例（6%）患者伴有刺激和阻塞性症状。生活质量受到下尿路症状的干扰，这种干扰与疾病的严重程度相一致。抗帕金森药物对下尿路症状的影响尚不确定。下尿路症状的发生率似乎与性别无关，但梗阻性症状在男性患者中普遍存在。结论：本研究表明，帕金森病患者的排尿功能障碍在晚期（大于或等于Hoehn和Yahr残疾的3期）逐渐发展。国际前列腺症状评分可用于评估男性和女性神经退行性疾病的排尿功能障碍，而不仅仅是反映前列腺症状。
Objectives-To find the incidence of voiding dysfunction in Parkinson's disease and to examine the relation between the voiding dysfunction and various indices of the disease (disease severity, disease duration, age, sex, and treatment with antiparkisonian drugs), the presence of voiding dysfunction was quantitatively estimated in patients sampled on the unselected (consecutive) basis.Methods-Using the international prostate symptom score, lower urinary tract symptoms were quantitatively evaluated in all patients with Parkinson's disease visiting this neurological clinic during 1 month.Results-Of the 203 patients who had completed the questionnaire, 55 (27%) were considered to have symptomatic voiding dysfunction. The degree of lower urinary tract symptoms in these patients was well correlated with the severity of the disease rather than with the disease duration or the age. Thirty three (16%) patients had irritative symptoms alone, whereas three (1.5%) patients had obstructive symptoms alone. The irritative and obstructive symptoms were concomitant in 13 (6%) patients. Quality of life was disturbed by lower urinary tract symptoms, and this disturbance paralleled the severity of the disease. The influence of antiparkisonian drugs on the lower urinary tract symptoms was uncertain. The incidence of lower urinary tract symptoms seemed to be independent of sex, but obstructive symptoms were prevalent in male patients.Conclusions-This study suggests that voiding dysfunction in patients with Parkinson's disease progressively develops at advanced stages (greater than or equal to Hoehn and Yahr stage 3 of the disability). The international prostate symptom score is useful in evaluating the voiding dysfunction of neurodegenerative disease in both men and women, not only reflecting prostatic symptoms.