Relationship between plasma glutathione levels and cardiovascular disease in a defined population - The Hisayama study
Relationship between plasma glutathione levels and cardiovascular disease in a defined population - The Hisayama study
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DOI：
10.1161/01.str.0000138022.86509.2d
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发表时间：
2004-09-01
期刊：
影响因子：
8.3
通讯作者：
Iida, M
中科院分区：
文献类型：
--
作者：
Shimizu, H;Kiyohara, Y;Iida, M
背景和目的-谷胱甘肽(GSH)似乎具有显著的抗氧化活性，因此可以预防心血管疾病(CVD)。然而，关于这一主题的报道很少。方法：采用条件Logistic回归分析方法，对134例CVD患者和435例年龄、性别匹配的健康对照组空腹血浆总GSH水平与CVD的关系进行了分析。结果：所有CVD患者的血浆总GSH水平均低于对照组(3.06Mumol/L和3.71Mumol/L；P=0.0001)。在脑血管病类型中，脑梗死组(2.98mumol/L；P=0.001)和脑出血组(2.51mumol/L，P=0.0027)均显著低于相应对照组。蛛网膜下腔出血(3.45mumol/L；P=0.36)和心肌梗死(3.65mumol/L，P=0.69)也有同样的趋势，但差异无统计学意义。在调整其他混杂因素后，第三个四分位数(调整后的优势比为041；95%CI为0.21~0.77)和第四个四分位数(调整后的优势比为0.25；95%CI为0.12~0.51)发生心血管疾病的风险显著低于第一个四分位数。这种关联在腔隙性脑梗塞或脑出血患者中最为显著。结论--这些发现提示血浆tGSH水平降低是心血管疾病的危险因素，尤其是对脑小血管疾病。
Background and Purpose-Glutathione (GSH) appears to have marked antioxidant activities and therefore may prevent cardiovascular disease (CVD). However, there are very few reports on this subject. In a community-based case-control study, we tested the hypothesis that low levels of plasma GSH are closely associated with CVD and its clinical types.Methods-The association between fasting plasma total GSH (tGSH) levels and CVD were assessed using conditional logistic regression analysis among 134 CVD cases and 435 age- and sex-matched healthy control subjects.Results-Mean tGSH concentrations were lower in all CVD cases than in the control subjects (3.06 versus 3.71 mumol/L; P=0.0001). Among the CVD types, both the cerebral infarction cases (2.98 versus 3.59 mumol/L; P=0.001) and cerebral hemorrhage cases (2.51 versus 3.43 mumol/L; P=0.0027) had significantly lower tGSH levels than the corresponding control groups had. The same tendency was observed for cases of subarachnoid hemorrhage (3.45 versus 3.83 mumol/L; P=0.36) and myocardial infarction (3.65 versus 3.77 mumol/L; P=0.69), but these differences were not statistically significant. After adjustment for other confounding factors, the risk of CVD was significantly lower in the third (adjusted odds ratio, 041; 95% CI, 0.21 to 0.77) and the fourth quartiles (adjusted odds ratio, 0.25; 95% CI, 0.12 to 0.51) than in the first. This association was most prominent in patients with lacunar infarction or cerebral hemorrhage.Conclusions-These findings suggest that reduced plasma tGSH levels are a risk factor for CVD, especially for cerebral small vessel disease.