Hydrogen therapy may be an effective and specific novel treatment for acute radiation syndrome
Hydrogen therapy may be an effective and specific novel treatment for acute radiation syndrome
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DOI：
10.1016/j.mehy.2009.07.017
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发表时间：
2010-01-01
影响因子：
4.7
通讯作者：
Cai, Jianming
中科院分区：
文献类型：
--
作者：
Liu, Cong;Cui, Jianguo;Cai, Jianming
氢是宇宙中最丰富的化学元素，但很少被视为治疗气体。最近的研究表明，吸入氢气（H-2）具有抗氧化和抗凋亡活性，通过选择性地减少羟基和过氧亚硝酸根自由基，保护脑免受缺血再灌注损伤和中风。众所周知，超过一半的电离辐射引起的细胞损伤是由羟基自由基引起的。研究表明，减少羟基自由基可以显着提高细胞免受辐射损伤的保护。以同样的方式。我们推测氢疗法可能是治疗急性放射综合征的一种有效、特异和独特的治疗方法。(C)2009爱思唯尔有限公司保留所有权利。
Hydrogen is the most abundant chemical element in the universe, however, it is seldom regarded as a therapeutic gas. Recent studies show that inhaled hydrogen gas (H-2) has antioxidant and antiapoptotic activities that protect the brain against ischemia-reperfusion injury and stroke by selectively reducing hydroxyl and peroxynitrite radicals. It is also well known that more than a half of the ionizing radiation-induced cellular damage is caused by hydroxyl radicals. Studies have show that reducing hydroxyl radicals can significantly improve the protection of cells from radiation damage. In like manner. we hypothesize that hydrogen therapy may be an effective, specific and unique treatment for acute radiation syndrome. (C) 2009 Elsevier Ltd. All rights reserved.