The IGF system and breast cancer
The IGF system and breast cancer
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DOI：
10.1677/erc.0.0080197
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发表时间：
2001-09-01
影响因子：
3.9
通讯作者：
Yee, D
中科院分区：
文献类型：
--
作者：
Sachdev, D;Yee, D
IGF系统成分与乳腺癌进展有关。IGF-I和IGF-II是促有丝分裂和抗凋亡肽，其影响包括正常和转化的乳腺上皮细胞在内的各种细胞类型的增殖。IGF系统是乳腺癌中关键的生长调节途径。由于IGF系统的各种成分直接或间接参与乳腺癌，因此必须更好地了解这些成分，以便开发更具体的治疗乳腺癌的治疗策略。
The IGF system components have been implicated in breast cancer progression. IGF-l and IGF-II are mitogenic and anti-apoptotic peptides that influence the proliferation of various cell types including normal and transformed breast epithelial cells. The IGF system is a key growth regulatory pathway in breast cancer. As various components of the IGF system have been directly or indirectly implicated in breast cancer, it is essential to gain a better understanding of these in order to develop more specific therapeutic strategies for treating breast cancer.