Performance of the Fecal Immunochemical Test Is Not Decreased by High Ambient Temperature in the Rapid Return System
Performance of the Fecal Immunochemical Test Is Not Decreased by High Ambient Temperature in the Rapid Return System
复制标题
DOI：
10.1007/s10620-012-2139-y
复制
发表时间：
2012-08-01
影响因子：
3.1
通讯作者：
Hwang, Sang-Hyun
中科院分区：
文献类型：
--
作者：
Cha, Jae Myung;Lee, Joung Il;Hwang, Sang-Hyun
在高环境温度下，粪便免疫化学试验的血红蛋白浓度可能会降低，FIT中的粪便样本可能会暴露于高环境temperature. This研究的目的是确定在筛查当天的高环境温度是否会降低FIT在基于人群的筛查中的性能。比较了低温度（< 10.0 A摄氏度）和高温度（千分之一日元25.0 A摄氏度）组之间的粪便血红蛋白浓度、FIT阳性概率和结直肠肿瘤检测率。分析了8，316名参与者的FIT结果。低温组的平均log（10）Hb浓度显著高于高温组（0.36 vs. 0.25 ng/ml，p = 0.000）。回归分析表明，温度升高1 A摄氏度会使正FIT的概率降低3.1%。然而，我们发现两组之间的FIT阳性率和大肠肿瘤的检出率没有差异。在多变量分析中，高环境温度不是阳性FIT结果或结直肠肿瘤检测的显著风险因素。应考虑粪便血红蛋白在高环境温度下的潜在不稳定性;然而，其对FIT性能的影响可能会因粪便样本暴露于高环境温度的时间较短而减弱（即，快速返回系统）。
Hemoglobin concentration of fecal immunochemical test may be decreased at high ambient temperature, and fecal samples in FIT may be exposed to high ambient temperature.The aim of this study was to determine whether a high ambient temperature on the day of screening may decrease the performance of FITs in population-based screening.We performed FITs for asymptomatic participants aged 50 years or older. Fecal hemoglobin concentration, the probability of a positive FIT and a detection rate of colorectal neoplasms were compared between low (< 10.0 A degrees C) and high (a parts per thousand yen25.0 A degrees C) temperature groups.The FIT results for 8,316 participants were analyzed. The mean log(10) Hb concentration in the low temperature group was significantly higher than those in the high temperature group (0.36 vs. 0.25 ng/ml, p = 0.000). Regression analysis showed that an increase in temperature of 1 A degrees C reduced the probability of a positive FIT by 3.1 %. However, we found no differences between the two groups in the FIT positive rate and detection rate of colorectal neoplasms. In multivariate analysis, high ambient temperature was not a significant risk factor for either the positive FIT result or the detection of colorectal neoplasms.Potential instability of fecal hemoglobin at high ambient temperatures should be considered; however, its influence on performance of FIT may be attenuated by the short exposure time of fecal samples to high ambient temperature (i.e., rapid return system).