Chemical synthesis of the second messenger nicotinic acid adenine dinucleotide phosphate by total synthesis of nicotinamide adenine dinucleotide phosphate
Chemical synthesis of the second messenger nicotinic acid adenine dinucleotide phosphate by total synthesis of nicotinamide adenine dinucleotide phosphate
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DOI：
10.1002/anie.200460054
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发表时间：
2004-01-01
影响因子：
16.6
通讯作者：
Potter, BVL
中科院分区：
文献类型：
--
作者：
Dowden, J;Moreau, C;Potter, BVL
信号二核苷酸：首次报道了烟酰胺腺嘌呤二核苷酸磷酸（NADP）的单异构体合成。安装和维护敏感的磷酸盐和吡啶功能是成功的关键。值得注意的是，NADP被转化为哺乳动物重要的第二信使NAADP。该图显示了Ca2+离子释放活性的生物学评价，证实了NAADP的身份。
Signaling dinucleotides: The first single-isomer synthesis of nicotinamide adenine dinucleotide phosphate (NADP) is reported. Installation and maintenance of sensitive phosphate and pyridinium functionalities were key to success. Significantly, conversion of NADP into the important mammalian second messenger NAADP was achieved. The graph shows the biological evaluation of the activity of the release of Ca2+ ions, which confirms the identity of NAADP.