Prevalence of orthostatic hypotension in Parkinson's disease: a systematic review and meta-analysis.

Prevalence of orthostatic hypotension in Parkinson's disease: a systematic review and meta-analysis.
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DOI:
10.1016/j.parkreldis.2011.04.016
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发表时间:
2011-12
影响因子:
4.1
通讯作者:
de Bie RM
de Bie RM
中科院分区:
医学2区
文献类型:
--
作者:
Velseboer DC;de Haan RJ;Wieling W;Goldstein DS;de Bie RM

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虽然直立性低血压(OH)被认为是帕金森病(PD)的主要非运动性症状之一,但关于其在PD中的患病率却没有一致的证据。为了更准确地评估帕金森病患者中OH的患病率,我们对文献进行了系统回顾。从PubMed和Embase的预定义纳入标准搜索中,我们确定了截至2009年12月发表的研究。研究中的患病率数据使用非线性随机效应荟萃分析进行汇总。我们发现了25项研究,可以从这些研究中计算出OH的患病率。对帕金森病患者OH点患病率的综合估计为30.1%(95%可信区间:22.9%~38.4%)。我们发现研究之间有很大的统计异质性,这不能通过几个子组分析来减少。据估计,帕金森病患者中OH的患病率为30%。然而,由于研究之间存在很大的异质性,因此应该谨慎地解释这种合并估计。需要来自未经选择的基于人群的队列的更多数据。
Although orthostatic hypotension (OH) is recognized as one of the main non-motor symptoms of Parkinson’s disease (PD), there is inconsistent evidence about the prevalence of OH in PD. To estimate the prevalence of OH in PD more precisely we conducted a systematic review of the literature. From PubMed and Embase searches with predefined inclusion criteria, we identified studies published up till December 2009. Prevalence numbers from studies were pooled using a non-linear random-effects meta-analysis. We found 25 studies from which the prevalence of OH could be calculated. The pooled estimate of the point prevalence of OH in PD was 30.1% (95% CI: 22.9% to 38.4%). We found a large statistical heterogeneity between studies which could not be reduced by several subgroup analyses. The estimated prevalence of OH in PD is 30%. However, due to the large heterogeneity between studies this pooled estimate should be interpreted with caution. More data from unselected population-based cohorts are needed.
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