Prevalence of orthostatic hypotension in Parkinson's disease: a systematic review and meta-analysis.
Prevalence of orthostatic hypotension in Parkinson's disease: a systematic review and meta-analysis.
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DOI:
10.1016/j.parkreldis.2011.04.016
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发表时间:
2011-12
影响因子:
4.1
通讯作者:
de Bie RM
中科院分区:
文献类型:
--
作者:
Velseboer DC;de Haan RJ;Wieling W;Goldstein DS;de Bie RM
Although orthostatic hypotension (OH) is recognized as one of the main non-motor symptoms of Parkinson’s disease (PD), there is inconsistent evidence about the prevalence of OH in PD. To estimate the prevalence of OH in PD more precisely we conducted a systematic review of the literature. From PubMed and Embase searches with predefined inclusion criteria, we identified studies published up till December 2009. Prevalence numbers from studies were pooled using a non-linear random-effects meta-analysis. We found 25 studies from which the prevalence of OH could be calculated. The pooled estimate of the point prevalence of OH in PD was 30.1% (95% CI: 22.9% to 38.4%). We found a large statistical heterogeneity between studies which could not be reduced by several subgroup analyses. The estimated prevalence of OH in PD is 30%. However, due to the large heterogeneity between studies this pooled estimate should be interpreted with caution. More data from unselected population-based cohorts are needed.
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影响因子:
3
作者:
LEBOEUFYDE, C;LAURITSEN, JM
通讯作者:
LAURITSEN, JM
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通讯作者:
Zeppezauer, M
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Chelimsky, Thomas C.
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