Single Fiber Recording of the Ventricular Response to Induced Hypothermia in the Anesthetized Dog: Correlation with Multicellular Parameters
Single Fiber Recording of the Ventricular Response to Induced Hypothermia in the Anesthetized Dog: Correlation with Multicellular Parameters
复制标题
麻醉犬诱导低温心室反应的单纤维记录：与多细胞参数的相关性
DOI：
10.1161/01.res.7.6.880
复制
发表时间：
1959
影响因子：
20.1
通讯作者：
D. Amory
中科院分区：
文献类型：
--
作者：
T. C. West;E. Frederickson;D. Amory
用微电极技术记录麻醉开胸犬的心室膜电位。同时记录心室内压、心电图和食管温度。通过体外冷却方法诱导低体温。给出了在38 ~ 22 ℃温度范围内观察到的参数数据.自发性室颤的平均温度约为22 ℃。低温增加单纤维动作电位时程，主要是通过延长平台期。去极化和终末复极受影响较小。动作电位振幅和静息电位无变化。动作电位时程的变化作为不同心率的函数，随着冷却变得更加明显。随着低温的进展，早期复极过程中动作电位形状的特征性变化变得明显。将单纤维动作电位的低温变化与心电图和压力曲线的变化进行比较。低温心室颤动时单根纤维的记录显示动作电位时程明显缩短。
Ventricular membrane Potentials were recorded by the microelectrode technic in anesthetized, open-chest dogs. Concurrently, intraventricular pressure, electrocardiogram and esophageal temperature were recorded. Hypothermia was induced by an extracorporeal cooling method. Data on the parameters observed are presented for a temperature range from 38 to 22 C. The mean temperature for spontaneous ventricular fibrillation was approximately 22 C. Hypothermia increased single fiber action potential duration, primarily by prolonging the plateau phase. Depolarization and terminal repolarization were less affected. Action potential amplitude and resting potential were not changed. Change in action potential duration as a function of varying heart rate became more pronounced with cooling. A characteristic change in action potential shape during early repolarization became evident as hypothermia progressed. Hypothermic changes in the single fiber action potential are compared with changes in the electrocardiogram and the pressure curve. Recordings made from single fibers during hypothermic ventricular fibrillation showed a marked shortening in action potential duration.